Abstract
Previous research has demonstrated that serum lipid profile is associated with cognitive function as well as brain structure and function in middle-aged, elderly, and clinical populations. However, the nature and extent of lipids-brain-cognition relationships in young adulthood are largely unknown. In this study, 157 healthy young adults underwent resting-state functional MRI scans. Functional connectivity between and within 14 functional networks were calculated using independent component analysis. Peripheral venous blood samples were collected to measure serum lipids. Working memory was assessed using a 3-back task. Linear regression, correlation, and mediation analyses were conducted to test for potential associations between serum lipids, inter- and intranetwork functional connectivity, and working memory performance. We found that higher serum triglyceride (TG) level was correlated with stronger connectivity between left frontoparietal and ventral attention networks, between right frontoparietal and dorsal attention networks, between right frontoparietal and dorsal sensorimotor networks, between right frontoparietal and lateral visual networks, and between salience (SN) and ventral sensorimotor (vSMN) networks, as well as...Continue Reading
References
Sep 18, 2001·Human Brain Mapping·V D CalhounJ J Pekar
Jul 16, 2003·Cellular and Molecular Life Sciences : CMLS·F W Pfrieger
Jun 15, 2004·Human Brain Mapping·Vincent G van de VenDavid E J Linden
Apr 23, 2005·Human Brain Mapping·Adrian M OwenEd Bullmore
Nov 2, 2005·NeuroImage·M De LucaS M Smith
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Mar 21, 2007·NeuroImage·Randy L Buckner, Justin L Vincent
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Sep 1, 2007·NeuroImage·John Ashburner
Oct 20, 2007·Critical Care Medicine·Rodrigo Cartin-CebaOgnjen Gajic
Nov 21, 2007·Neurobiology of Aging·A SolomonM Kivipelto
May 31, 2008·Nutritional Neuroscience·Mathew H GendleCindy A Novak
Apr 20, 2010·Journal of the American Geriatrics Society·Chandra A ReynoldsNancy L Pedersen
Aug 21, 2010·Frontiers in Aging Neuroscience·Michael A WardSterling C Johnson
Apr 16, 2011·Dementia and Geriatric Cognitive Disorders·Mitzi M GonzalesAndreana P Haley
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Sep 28, 2013·Brain Structure & Function·Feng LiuHuafu Chen
Jun 24, 2014·Radiology·Frederik BarkhofSerge A R B Rombouts
Aug 1, 2014·Brain Topography·Feng LiuHuafu Chen
Nov 5, 2014·Brain Structure & Function·Gabriel Gonzalez-EscamillaJose L Cantero
May 21, 2015·Lipids in Health and Disease·Wenqing XiaShaohua Wang
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Ting ZhangZhanjun Zhang
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Apr 27, 2016·The International Journal of Neuroscience·Kristyn A BatesRalph N Martins
Jul 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anders EklundHans Knutsson
Oct 12, 2016·Human Brain Mapping·Feng LiuHuafu Chen
Apr 4, 2017·Human Brain Mapping·Jeffrey M SpielbergDavid H Salat
Jun 13, 2017·Neuropsychology·Vishnu ParthasarathyJoel H Kramer
Sep 17, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Melinda C PowerRebecca F Gottesman
May 20, 2018·Journal of Diabetes Investigation·Yue SunTimothy Kwok
Jan 17, 2019·Metabolic Brain Disease·Con StoughAndrew Scholey
Mar 12, 2019·NeuroImage. Clinical·Ryuta KinnoKenjiro Ono
Apr 24, 2019·Neuroradiology·Han ShanBaoci Shan