Large-scale intrinsic functional network organization along the long axis of the human medial temporal lobe

Brain Structure & Function
Shaozheng QinV Menon

Abstract

The medial temporal lobe (MTL), encompassing the hippocampus and parahippocampal gyrus (PHG), is a heterogeneous structure which plays a critical role in memory and cognition. Here, we investigate functional architecture of the human MTL along the long axis of the hippocampus and PHG. The hippocampus showed stronger connectivity with striatum, ventral tegmental area and amygdala-regions important for integrating reward and affective signals, whereas the PHG showed stronger connectivity with unimodal and polymodal association cortices. In the hippocampus, the anterior node showed stronger connectivity with the anterior medial temporal lobe and the posterior node showed stronger connectivity with widely distributed cortical and subcortical regions including those involved in sensory and reward processing. In the PHG, differences were characterized by a gradient of increasing anterior-to-posterior connectivity with core nodes of the default mode network. Left and right MTL connectivity patterns were remarkably similar, except for stronger left than right MTL connectivity with regions in the left MTL, the ventral striatum and default mode network. Graph theoretical analysis of MTL-based networks revealed higher node centrality of t...Continue Reading

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Citations

Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Eun Hyun SeoIl Han Choo
Aug 3, 2018·Development and Psychopathology·Bea R H van den BerghMaarten Mennes
Feb 24, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·James AlleboneSarah J Wilson
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Oct 7, 2020·Journal of Neural Engineering·Christoforos A PapasavvasYujiang Wang
Apr 1, 2021·The European Journal of Neuroscience·Laura EzamaNiels Janssen
Jul 29, 2021·Hippocampus·Daniel Yochai PanitzAvi Mendelsohn
Mar 18, 2021·Brain : a Journal of Neurology·Qiongling LiBoris C Bernhardt

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