PMID: 9177962Apr 1, 1997Paper

Large-scale multicentre study of fluconazole in the treatment of hospitalised patients with fungal infections. Multicentre European Study Group

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
P F Troke

Abstract

The purpose of this prospective, open-label, noncomparative, multicentre study was to evaluate the efficacy and safety of fluconazole in the treatment of hospitalised patients with mycoses. A total of 587 patients with diagnosed fungal infections were enrolled. Fluconazole was given orally or intravenously in a 200 or 400 mg loading dose, followed by 100 or 200 mg once daily. The most common candidal infections were fungemia, esophageal candidiasis, bronchopulmonary candidiasis, peritonitis, oropharyngeal candidiasis, urinary tract infection and deep wound infection. Meningitis was the most common cryptococcal infection. Of the 291 evaluable patients with candidiasis, 96% (70/73) of AIDS patients and 79% (171/218) of non-AIDS patients were clinically cured or improved. Of the 36 evaluable patients with cryptococcosis, 69% (20/29) of AIDS patients and 100% (7/7) of non-AIDS patients responded clinically. The overall mycological eradication rate was 85%; eradication was similar in patients with and without AIDS. Most adverse events during fluconazole therapy were mild to moderate in severity. This investigation confirms the results of previous studies demonstrating high response rates to fluconazole therapy in AIDS and non-AIDS p...Continue Reading

References

Apr 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Pfaller, R Wenzel
May 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Milatovic, A Voss
Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W G Powderly
Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M DiazE G Arathoon
Apr 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Nolla-SalasA Sitges-Serra
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·D W Denning
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·R J Hay
May 1, 1991·Reviews of Infectious Diseases·J R PerfectW A Schell
Aug 1, 1991·The American Journal of Medicine·C A KauffmanD R Weber
Sep 16, 1991·The American Journal of Medicine·D R SchabergR P Gaynes
Jul 1, 1991·The Journal of Antimicrobial Chemotherapy·M D Richardson
Jul 1, 1991·The Journal of Antimicrobial Chemotherapy·R J Hay
Mar 1, 1990·Reviews of Infectious Diseases·K W BrammerJ K Faulkner
Nov 1, 1990·Diagnostic Microbiology and Infectious Disease·A M SugarR D Diamond
Feb 1, 1989·The Journal of Antimicrobial Chemotherapy·J Cohen
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·H Ikemoto
May 1, 1988·The Journal of Antimicrobial Chemotherapy·J W Van't WoutR van Furth
Jan 1, 1987·Reviews of Infectious Diseases·P PhillipsJ R Graybill
Apr 1, 1995·American Journal of Ophthalmology·J K LuttrullH A Oster
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P G PappasW E Dismukes
Jan 1, 1995·British Journal of Urology·U SimşekM Ozyurt
Oct 1, 1994·The Journal of Antimicrobial Chemotherapy·K A KostiukB J Guglielmo
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V KrcméryA Danisovicová
Jan 1, 1994·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·S F Urbak, T Degn
Apr 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Presterl, W Graninger
Jan 1, 1993·The American Journal of Medicine·A R TunkelB Wispelwey

❮ Previous
Next ❯

Citations

May 9, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·W Behrens-Baumann
Apr 20, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S B GiroisB G P Revol
Feb 16, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S B GiroisB G P Revol
Jul 8, 1999·Mycoses·R SchwarzeL Pittrow
Aug 26, 1998·Mycoses·R SchwarzeL Pittrow
May 11, 2001·The Annals of Pharmacotherapy·T TakahashiA Iwamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.