DOI: 10.1101/002782Feb 17, 2014Paper

Large-scale non-targeted metabolomic profiling in three human population-based studies

BioRxiv : the Preprint Server for Biology
Andrea GannaErik Ingelsson


Non-targeted metabolomic profiling is used to simultaneously assess a large part of the metabolome in a biological sample. Here, we describe the dataset of a large UPLC-Q-TOFMS-based metabolomic profiling effort using plasma and serum samples from participants in three Swedish population-based studies of middle-aged and older human subjects: TwinGene, ULSAM and PIVUS, including more than 3,600 participants in total. At present, more than 200 metabolites have been manually annotated in the three cohorts using an in-house library of standards and publically available spectral databases. Data available at the Metabolights repository include individual raw unprocessed data, processed data, basic demographic variables and spectra of annotated metabolites. Additional phenotypical and genetic data is available upon request to cohort steering committees.

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