Large-Scale Organization of the Hand Action Observation Network in Individuals Born Without Hands

Cerebral Cortex
Gilles VannuscorpsAlfonso Caramazza

Abstract

The human high-level visual cortex comprises regions specialized for the processing of distinct types of stimuli, such as objects, animals, and human actions. How does this specialization emerge? Here, we investigated the role of effector-specific visuomotor coupling experience in shaping the organization of the action observation network (AON) as a window on this question. Observed body movements are frequently coupled with corresponding motor codes, e.g., during monitoring one's own movements and imitation, resulting in bidirectionally connected circuits between areas involved in body movements observation (e.g., of the hand) and the motor codes involved in their execution. If the organization of the AON is shaped by this effector-specific visuomotor coupling, then, it should not form for body movements that do not belong to individuals' motor repertoire. To test this prediction, we used fMRI to investigate the spatial arrangement and functional properties of the hand and foot action observation circuits in individuals born without upper limbs. Multivoxel pattern decoding, pattern similarity, and univariate analyses revealed an intact hand AON in the individuals born without upper limbs. This suggests that the organization of...Continue Reading

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Citations

Feb 27, 2020·Cognitive Neuropsychology·Gilles Vannuscorps, Alfonso Caramazza
May 5, 2020·ELife·Gilles VannuscorpsAlfonso Caramazza
Jan 19, 2019·Nature Communications·Moritz F Wurm, Alfonso Caramazza
Jan 9, 2021·Journal of Cognitive Neuroscience·Gilles VannuscorpsAlfonso Caramazza
Nov 24, 2020·Open Mind : Discoveries in Cognitive Science·Erez FreudJacqueline C Snow
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yuqi LiuElla Striem-Amit

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