Jan 23, 2008

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete

PLoS Genetics
Colette M JohnstonMark T Ross

Abstract

X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.

  • References36
  • Citations83

References

  • References36
  • Citations83

Citations

Mentioned in this Paper

KDM5C gene
Y Chromosome
PNPLA4 gene
Abnormal Degeneration
Imbalance
Chromosomes, Human, X
EIF2S3 gene
SMC1A gene
CA5B gene
EIF1AX gene

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