Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.

PLoS Genetics
Colette M JohnstonMark T Ross

Abstract

X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.

References

Jun 15, 1979·Science·L J ShapiroG Romeo
Oct 18, 1984·The New England Journal of Medicine·C J CurryL J Shapiro
Jan 1, 1994·Annual Review of Genetics·B S BakerI Marín
Jun 1, 1997·American Journal of Human Genetics·C J BrownH F Willard
May 16, 1998·Human Molecular Genetics·A GreenfieldP Koopman
Nov 5, 1999·Science·B T Lahn, D C Page
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·L CarrelH F Willard
Apr 5, 2002·Advances in Genetics·Victoria H Meller, Mitzi I Kuroda
Sep 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R G DAVIDSONB CHILDS
Apr 29, 2004·European Journal of Human Genetics : EJHG·Ian W CraigLeonard C Schalkwyk
Mar 18, 2005·Nature·Mark T RossDavid R Bentley
May 10, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazutaka ObamaYoichi Furukawa
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Jennifer C ChowCarolyn J Brown
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Dec 13, 2005·Nature Genetics·Di Kim Nguyen, Christine M Disteche
Dec 20, 2005·PLoS Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Mar 2, 2006·Journal of Biology·Vaijayanti GuptaBrian Oliver
Sep 5, 2006·Genomics·Zohreh TalebizadehMerlin G Butler
Dec 14, 2006·Human Molecular Genetics·Allan F McRaePeter M Visscher
Feb 10, 2007·Science·Barbara E StrangerEmmanouil T Dermitzakis
Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Jan 22, 2011·Genetika·M A Ferguson-Smith, W Rens

❮ Previous
Next ❯

Citations

Feb 22, 2014·Genome Biology and Evolution·Gilbert SmithAdriana D Briscoe
Dec 18, 2013·Science·Tim WangEric S Lander
Jul 6, 2013·Science·Ryan ListerJoseph R Ecker
Nov 1, 2013·Cellular and Molecular Life Sciences : CMLS·Eugénie PessiaGabriel A B Marais
Apr 16, 2014·Nature Reviews. Genetics·Xinxian DengChristine M Disteche
Jan 7, 2014·Frontiers in Neuroendocrinology·Kimberly H CoxEmilie F Rissman
Sep 15, 2012·Annual Review of Genetics·Christine M Disteche
Jul 26, 2008·PLoS Genetics·Janine E DeakinJennifer A Marshall Graves
Jan 1, 2008·Cytogenetic and Genome Research·H M Lachman
Dec 10, 2009·PLoS Genetics·Xinxian DengChristine M Disteche
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yukio YasukochiSherman M Weissman
Apr 7, 2010·Genome Research·Fan YangChristine M Disteche
Apr 22, 2011·Genome Biology and Evolution·James R Walters, Thomas J Hardcastle
May 27, 2011·Human Genetics·Joel B BerletchChristine M Disteche
Aug 4, 2011·Bioinformatics·Yi-Hui ZhouFred A Wright
Aug 25, 2011·Genome Research·Andrew J SharpStylianos E Antonarakis
Feb 9, 2012·Stem Cells and Development·Pablo Bermejo-AlvarezAlfonso Gutierrez-Adan
Sep 17, 2013·PLoS Genetics·Irene Hernando-HerraezTomas Marques-Bonet
Jun 11, 2010·Molecular Biology and Evolution·Chungoo ParkKateryna D Makova
Oct 17, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Sharan K SidhuCarolyn J Brown
Oct 6, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Katie E ProtheroLaura Carrel
Oct 6, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Carolyn A Bondy, Clara Cheng
Oct 6, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Janine E DeakinJennifer A Marshall Graves
May 10, 2011·Human Genetics·Christine YangCarolyn J Brown
Jun 25, 2010·Genome Biology·Joel B BerletchChristine M Disteche
Aug 30, 2008·Annual Review of Genetics·Bernhard Payer, Jeannie T Lee
May 18, 2010·Chromosoma·Elena V DementyevaSuren M Zakian
Jun 18, 2014·FEBS Letters·Ronan Chaligné, Edith Heard
Jun 11, 2015·European Journal of Human Genetics : EJHG·Ching MoeyCheryl Shoubridge
Jan 26, 2016·Seminars in Cell & Developmental Biology·Deanne J Whitworth, Andrew J Pask
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Arthur P ArnoldShayna M Williams-Burris
Nov 15, 2011·Trends in Genetics : TIG·Arthur P Arnold
Dec 14, 2011·Autoimmunity Reviews·Sabine Oertelt-Prigione
Feb 22, 2011·Trends in Genetics : TIG·Patrick J Wijchers, Richard J Festenstein
Sep 8, 2010·Hormones and Behavior·Jun Xu, Megan Andreassi
Jan 1, 2016·Biology of Sex Differences·Bradley P BalatonCarolyn J Brown
Dec 30, 2014·BMC Evolutionary Biology·Claudia L Rodríguez-DelgadoPaul D Waters
Aug 6, 2011·Journal of Neurodevelopmental Disorders·Rebecca Christine Knickmeyer, Marsha Davenport
May 30, 2009·Current Opinion in Cell Biology·Jennifer Chow, Edith Heard
Apr 11, 2009·Trends in Genetics : TIG·Judith E Mank

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Datasets Mentioned

BETA
GSE6536

Software Mentioned

ABI PRISM GeneMapper

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