Large trials, new knowledge: the changing face of COPD management

The European Respiratory Journal
Anthony De Soyza, Peter M A Calverley

Abstract

Large, well-designed, drug-treatment trials have allowed useful advances to be made in the treatment and diagnosis of chronic obstructive pulmonary disease (COPD). The two main clinical trial designs that provide evidence of effectiveness are randomised controlled trials (RCTs) and observational studies. RCTs are generally considered to provide more robust evidence than that obtained from observational studies and can generate informative secondary analyses in addition to the primary research query. In COPD, however, well-designed comparator-controlled RCTs, although successful, have been shown to have some limitations, such as a lack of generalisability. The findings of observational studies, whilst prone to bias, can generate valuable data and have also provided useful information relating to the efficacy of treatments in the current COPD management guidelines. This review focuses on major COPD studies published since 2007 (including UPLIFT, TIOSPIR, ECLIPSE and COPDGene), and assesses the influence such RCTs and large observational studies have had on our knowledge of COPD, and how these may impact future trial designs.

References

May 22, 2003·The New England Journal of Medicine·Alfred FishmanUNKNOWN National Emphysema Treatment Trial Research Group
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
Aug 11, 2007·The European Respiratory Journal·S KestenD E Niewoehner
Sep 4, 2007·Lancet·Peter M A Calverley, Stephen I Rennard
Oct 6, 2007·American Journal of Respiratory and Critical Care Medicine·Jadwiga A WedzichaUNKNOWN INSPIRE Investigators
Jan 25, 2008·The European Respiratory Journal·J VestboUNKNOWN ECLIPSE investigators
May 31, 2008·American Journal of Respiratory and Critical Care Medicine·Bartolomé R CelliPeter M A Calverley
Jun 14, 2008·The European Respiratory Journal·M A PuhanH J Schünemann
Jun 27, 2008·The European Respiratory Journal·C G CoteB R Celli
Jun 27, 2008·The European Respiratory Journal·D M ManninoF Holguin
Jul 2, 2008·The European Respiratory Journal·O N KeeneJ A Anderson
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Terence A R SeemungalJadwiga A Wedzicha
Oct 2, 2008·The European Respiratory Journal·N S GodtfredsenJ Vestbo
Oct 7, 2008·The New England Journal of Medicine·Donald P TashkinUNKNOWN UPLIFT Study Investigators
Oct 7, 2008·The New England Journal of Medicine·John J Reilly
Dec 17, 2008·American Journal of Respiratory and Critical Care Medicine·John R HurstJadwiga A Wedzicha
Jan 20, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Michael Rawlins
Aug 1, 2009·American Journal of Respiratory and Critical Care Medicine·Tobias WelteRomain Kessler
Sep 1, 2009·Lancet·Richard BeasleyPhilippa Shirtcliffe
Sep 1, 2009·Lancet·Peter M A CalverleyUNKNOWN M2-124 and M2-125 study groups
Sep 1, 2009·Lancet·Sundeep S Salvi, Peter J Barnes
Sep 2, 2009·The European Respiratory Journal·P W JonesN Kline Leidy
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Bartolome CelliUNKNOWN UPLIFT Study Investigators
Nov 3, 2009·The European Respiratory Journal·O N KeeneP W Jones
Feb 27, 2010·The European Respiratory Journal·T TroostersUNKNOWN Uplift Investigators
Mar 11, 2010·COPD·Elizabeth A ReganJames D Crapo
May 14, 2010·American Journal of Respiratory and Critical Care Medicine·James F DonohueUNKNOWN INHANCE Study Investigators
Jun 26, 2010·Chest·Peter M A CalverleyUNKNOWN Investigating New Standards for Prophylaxis in Reduction of Exacerbations (INSPIRE) Investigators
Jun 29, 2010·BMJ : British Medical Journal·John O'ReillyUNKNOWN Guideline Development Group
Jul 27, 2010·American Journal of Respiratory and Critical Care Medicine·Sreekumar G PillaiUNKNOWN ECLIPSE and ICGN Investigators
Jul 28, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nancy Kline LeidyUNKNOWN EXACT-PRO Study Group
Aug 6, 2010·Thorax·Peter M A CalverleyUNKNOWN TORCH Investigators
Sep 14, 2010·Respiratory Research·Alvar AgustiUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
Sep 17, 2010·The New England Journal of Medicine·John R HurstUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Sep 24, 2010·The New England Journal of Medicine·Frank C SciurbaUNKNOWN VENT Study Research Group
Dec 17, 2010·The Clinical Respiratory Journal·Jørgen VestboPaul Wyatt Jones
Mar 25, 2011·The New England Journal of Medicine·Claus VogelmeierUNKNOWN POET-COPD Investigators
Mar 25, 2011·The European Respiratory Journal·A SinganayagamA T Hill

❮ Previous
Next ❯

Citations

Jan 20, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pim A de Jong, Firdaus Mohamed Hoesein
Jul 18, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter M A Calverley
Nov 2, 2015·The European Respiratory Journal·Peter Calverley
Jan 4, 2017·The European Respiratory Journal·Peter M A Calverley
Jan 2, 2016·The European Respiratory Journal·Pieter C Goeminne, Anthony De Soyza
May 26, 2017·The European Respiratory Journal·Nera Agabiti, Giuseppe Maria Corbo
Oct 14, 2017·The European Respiratory Journal·Roberto W Dal NegroUNKNOWN RESTORE study
Feb 19, 2019·ERJ Open Research·Nigel S CookFlorian S Gutzwiller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.