Large variations in prescriptions of gastrointestinal medications in hemodialysis patients on three continents: the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Hemodialysis International
George R BailieEric W Young

Abstract

Little is known about proton pump inhibitor (PPI) or H(2) receptor antagonist (HA) prescription patterns or regarding use of predictors in hemodialysis patients. Proton pump inhibitor and HA prescribing patterns were investigated in 8628 hemodialysis patients from seven countries enrolled in the prospective, observational Dialysis Outcomes and Practice Patterns Study. Logistic regression examined predictors associated with PPI and HA use, adjusting for age, sex, country, time with end-stage renal disease, medications, 14 comorbid conditions, and the association between the number of comorbid conditions and the prescription of gastrointestinal (GI) medications. In a cross-section from February 1, 2000, 3.4% to 36.9% of patients received an HA and 0.8% to 26.9% took a PPI, depending upon the country. From 1996 to 2001, the prescription of HAs declined while PPI use increased. Facility use of HAs and PPIs ranged from 0% to 94% of patients. H2 receptor antagonist or PPI use was significantly and independently associated with age, narcotic use, corticosteroids, acetaminophen, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, selective serotonin reuptake inhibitors, coronary artery disease history, cardiovascular disea...Continue Reading

References

Nov 5, 1998·Journal of Clinical Gastroenterology·M Odeh, A Oliven
Jun 7, 2000·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·H J ManleyD W Grabe
Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A A Fisher, D G Le Couteur
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Harold J ManleyRichard S Muther
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans StridEinar S Björnsson
Sep 13, 2003·Kidney International·Haimanot WasseCatherine O Stehman-Breen
Feb 6, 2004·Gastroenterology·Hashem B El-SeragJames E Everhart
Feb 20, 2004·Pharmacoepidemiology and Drug Safety·Gregory S CooperSiran M Koroukian
May 7, 2004·The American Journal of Gastroenterology·Nalini M Guda, Nimish Vakil
May 27, 2004·World Journal of Gastroenterology : WJG·Jin-Hai WangMing Tong
Jan 19, 2005·The American Journal of Gastroenterology·Kenneth R DeVaultUNKNOWN American College of Gastroenterology
Feb 3, 2005·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·David ArmstrongUNKNOWN Canadian Association of Gastroenterology GERD Consensus Group
Feb 8, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nancy A MasonEric W Young
Mar 17, 2005·Current Treatment Options in Gastroenterology·Mae F Go
Jul 5, 2005·The Laryngoscope·Kenneth W AltmanKevin B Weiss

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Citations

Jul 3, 2007·International Journal of Health Care Finance and Economics·Richard A Hirth
Jun 15, 2012·Journal of General Internal Medicine·James B WetmoreTheresa I Shireman
Jan 29, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Albert PowerNeill Duncan
Apr 18, 2009·Current Opinion in Nephrology and Hypertension·Suguru Yamamoto, Valentina Kon
Aug 12, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Yiqin ZuoValentina Kon
Nov 13, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ahraaz WyneRita S Suri
Feb 20, 2014·Indian Journal of Pharmacology·Chaitali S BajaitAmruta V Dawri
Apr 30, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Naoya KondoShunichi Fukuhara
Mar 25, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Vittal R NagarPaul A Sloan
Mar 10, 2020·Clinical and Experimental Nephrology·Hiroo KawarazakiTakeshi Nakata
Jul 28, 2020·Journal of Nephrology·Geoffroy Desbuissons, Lucile Mercadal
Dec 29, 2020·British Journal of Clinical Pharmacology·Sophie LiabeufUNKNOWN Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD REIN) Study Group

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