Large vessel vasculitides

Current Opinion in Rheumatology
M C CidJ M Grau

Abstract

During the past few years remarkable progress has been achieved in the understanding of the pathogenic mechanisms leading to vascular inflammation and injury in giant cell (temporal) arteritis. T lymphocytes are activated by specific recognition of a putative antigen residing in the arterial wall and, subsequently, activate macrophages that undergo a functional differentiation and contribute to vessel damage through various pathways. Vascular response to inflammation amplifies the inflammatory response through neovascularization and adhesion molecule expression. We are beginning to appreciate that products released by infiltrating inflammatory cells may play an important role in vessel occlusion and resulting ischemic complications. Concomitantly, synovitis underlying polymyalgia rheumatica musculoskeletal symptoms has been immunopathologically characterized and the nature of its relationship to giant cell arteritis is discussed. Although some components of the disease are highly corticosteroid responsive, other underlying pathogenic mechanisms may remain active. Long-term outcome is heterogeneous in patients with giant cell arteritis. Much less is known about the pathogenesis of Takayasu's arteritis. Recent work supports its a...Continue Reading

Citations

May 14, 1999·Arthritis and Rheumatism·C M Weyand, J J Goronzy
Mar 31, 2009·Der Radiologe·M BothM Heller
Jun 5, 1999·International Journal of Clinical & Laboratory Research·R RizziR Dammacco
Dec 21, 2000·Current Rheumatology Reports·N Mohan, G Kerr
Nov 30, 2000·Current Treatment Options in Neurology·S Zivkovic, P M Moore
Jul 21, 2004·International Journal of Cardiology·Kemal UretenMeral Calgüneri
Sep 12, 2000·International Journal of Cardiology·A KimuraF Numano
Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·K H LimC M Wong
Dec 18, 2004·Current Opinion in Rheumatology·Augusto Vaglio, Carlo Buzio
Jul 1, 2005·Arthritis Research & Therapy·Tanya R Da SylvaGillian E Wu
Jun 5, 2014·Current Cardiology Reports·Soumya ChatterjeeE Rene Rodriguez
Feb 1, 1965·Arthritis and Rheumatism·R L LIPSONH F POLLEY
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·George MedvedevAlex B Magil
Nov 26, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sunil Kumar ChauhanSoniya Nityanand
Nov 14, 2013·Scandinavian Journal of Rheumatology·M A AlbaL F Flores-Suárez
May 31, 2016·Annals of Vascular Surgery·Raffaele SerraStefano de Franciscis
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·C CantúM Martínez-Lavín
Jul 2, 2009·The Journal of Rheumatology·Oriol GaschRamon Pujol
Apr 9, 2005·Arthritis and Rheumatism·Carlo SalvaraniLuigi Boiardi
Nov 19, 2014·Current Opinion in Rheumatology·Sergio Prieto-GonzálezMaria C Cid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.

Related Papers

The Journal of Laryngology and Otology
Neville P ShineDonald P McShane
Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing
D StriderJ Ivey
© 2021 Meta ULC. All rights reserved