PMID: 31391329Aug 9, 2019Paper

Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor

The Netherlands Journal of Medicine
K YukawaE Sugiyama

Abstract

A 71-year-old female with advanced endometrial cancer was treated with pegfilgrastim. She developed a fever within seven days, and contrast-enhanced computed tomography scans repeated within three days revealed rapidly progressive thickening of the aortic wall. When clinicians administer PEGylated granulocyte-colony stimulating factor (G-CSF) to cancer patients, drug-associated vasculitis should be suspected. This report discusses the manifestation of G-CSF-associated large-vessel vasculitis (LVV).

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