Larger inhibition of visual pigment kinase in cones than in rods

Journal of Neurochemistry
Daisuke ArinobuSatoru Kawamura

Abstract

In the carp retina, visual pigment kinase, GRK1 (G-protein coupled receptor kinase 1) in rods and GRK7 in cones, is inhibited by a photoreceptor neuronal Ca(2+)-sensor protein, S-modulin (or recoverin) in rods and visinin (formerly named s26) in cones. Here, we compared Ca(2+)-dependent inhibition of GRK1 by S-modulin and that of GRK7 by visinin. First, the concentrations of S-modulin and visinin in the outer segment were estimated: the concentration of visinin (1.2 mM) was 20 times higher than that of S-modulin (53 μM). Based on the determined concentrations of the Ca(2+)-sensor proteins and the known dark Ca(2+) concentrations, we estimated that in situ Ca(2+)-dependent inhibition on GRK in cones would be 2.5 times higher than that in rods at the Ca(2+) concentration in the dark. Because GRK activity is approximately 100 times higher in cones than in rods [Proc. Natl Acad. Sci. USA 102 (2005) 21359], the range of Ca(2+)-dependent inhibition on GRK activity is more than 100 times wider in cones than in rods. The inhibitory effects of S-modulin and visinin on photoreceptor GRKs were indistinguishable, although these Ca(2+)-sensor proteins are expressed in a cell-type specific manner. The inhibition by these Ca(2+)-sensor protei...Continue Reading

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Citations

Jul 18, 2012·The Journal of General Physiology·Jingjing Zang, Hugh R Matthews
Sep 10, 2011·Pharmacology & Therapeutics·Eugenia V GurevichVsevolod V Gurevich
Nov 5, 2016·Scientific Reports·Shimpei TakitaSatoru Kawamura
Feb 26, 2015·The Journal of Biological Chemistry·Junko TomizukaSatoru Kawamura
Jan 9, 2019·Frontiers in Molecular Neuroscience·Jingjing Zang, Stephan C F Neuhauss
Sep 28, 2018·Open Biology·Trevor D Lamb, David M Hunt
Feb 13, 2015·The Journal of Biological Chemistry·Keisuke SakuraiVladimir J Kefalov

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