Larva migrans in squirrel monkeys experimentally infected with Baylisascaris potosis

Parasitology International
Toshihiro TokiwaYumi Une

Abstract

Roundworms of the genus Baylisascaris are natural parasites primarily of wild carnivores, and they can occasionally cause infection in humans and animals. Infection results in visceral larva migrans and/or neural larva migrans, which can be severe or fatal in some animals. Recently, Baylisascaris nematodes isolated from kinkajous (Potos flavus) and previously referred to as Baylisascaris procyonis were renamed as Baylisascaris potosis; however, data regarding the pathogenicity of B. potosis towards animals and humans are lacking. In the present study, we experimentally infected squirrel monkeys (Saimiri sciureus) with B. potosis to determine the suitability of the monkey as a primate model. We used embryonated eggs of B. potosis at two different doses (10,000 eggs and 100,000 eggs) and examined the animals at 30 days post-infection. Histopathological examination showed the presence of B. potosis larvae and infiltration of inflammatory cells around a central B. potosis larvae in the brain, intestines, and liver. Nevertheless, the monkeys showed no clinical signs associated with infection. Parasitological examination revealed the presence of B. potosis larvae in the intestines, liver, lung, muscles, brain, kidney, and diaphragm. ...Continue Reading

References

Apr 1, 1996·Journal of Medical Primatology·D S GarlickS H Schelling
Sep 11, 2004·The Journal of Parasitology·Hiroshi SatoHidefumi Furuoka
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J Murray, Kevin R Kazacos
Jan 24, 2013·Veterinary Parasitology·Christian Bauer
Apr 10, 2013·Veterinary Parasitology·Kensuke TairaYasuhide Saitoh
May 6, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ahmed Shoieb, Zaher A Radi
Jul 12, 2014·The Journal of Parasitology·T TokiwaY Une

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Citations

Nov 14, 2015·The Journal of Parasitology·Toshihiro TokiwaYumi Une

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