PMID: 8953426Nov 1, 1996Paper

Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi

Journal of Ethnopharmacology
Guido FrançoisGerhard Bringmann

Abstract

The larvicidal activity of dionocophylline A, a naphthylisoquinoline alkaloid derived from the tropical vine Triphyophyllum peltatum (Dioncophyllaceae), was investigated against the malaria vector Anopheles stephensi. In direct and indirect inhibition assays it was demonstrated that the younger larval stages were very sensitive towards this natural product, with LC50 values below 1 mg/l. Pronounced effects were observed within 4 h of exposure. Aging larvae, however, were less sensitive, while pupae were totally insensitive to the action of dioncophylline A. The transformations from larvae to pupae and from pupae to adult mosquitoes remained unaffected. Therefore, dioncophylline A can be regarded as a promising specific larvicide.

References

Jun 10, 1994·Journal of Medicinal Chemistry·M R BoydG M Cragg
Mar 1, 1994·Journal of Ethnopharmacology·S GeertsL Triest

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Citations

Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Emdad HossainJayanta Kumar Gupta
Apr 5, 2008·BMC Complementary and Alternative Medicine·Nandita ChowdhuryGoutam Chandra
Oct 5, 2011·Asian Pacific Journal of Tropical Medicine·Siddharthasankar BanerjeeGoutam Chandra
May 28, 2019·Natural Product Reports·Blaise Kimbadi LombeGerhard Bringmann
May 10, 2020·Environmental Science and Pollution Research International·Dinesh KumarVeena Agrawal

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