Laryngeal manifestations and pediatric laryngopharyngeal reflux

American Journal of Otolaryngology
Petros D KarkosTheocharis Apostolidis

Abstract

Pediatric laryngopharyngeal reflux (PLPR) refers to the atypical, otorhinolaryngological, and respiratory manifestations of gastroesophageal reflux disease in children. PLPR is believed to be an important inflammatory cofactor in disorders such as subglottic stenosis, asthma, recurrent croup, chronic rhinosinusitis, and middle ear infections. We review the literature, present clinical manifestations, and focus on diagnostic controversies and therapeutic challenges of PLPR in relation to laryngeal manifestations. Current evidence linking reflux to many laryngeal problems is mainly based on animal studies or uncontrolled human studies. Future efforts should concentrate on developing well-designed controlled studies to provide more information on diagnosis and treatment.

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Citations

Mar 3, 2009·The Journal of Laryngology and Otology·P D KarkosW J Issing
May 17, 2014·International Journal of Pediatric Otorhinolaryngology·Tomislav BaudoinOrjena Zaja
May 29, 2014·International Journal of Pediatric Otorhinolaryngology·Ryan L Sload, Matthew T Brigger
Oct 31, 2007·Nursing·Christy M Smith, David R White
Nov 18, 2015·International Journal of Pediatric Otorhinolaryngology·Benjamin L HodnettRaymond C Maguire
Aug 3, 2013·Pediatric Clinics of North America·Naren N VenkatesanMichael Underbrink
Oct 8, 2011·Allergologia et immunopathologia·S OzmenE Dibek Misirlioglu
Aug 19, 2015·International Journal of Pediatric Otorhinolaryngology·Francesca GalluzziWerner Garavello
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Zafer ArslanAysel Yöney
Jun 5, 2016·International Journal of Pediatric Otorhinolaryngology·Maartje M J SingendonkMichiel P van Wijk
Jul 24, 2008·The Annals of Otology, Rhinology, and Laryngology·Michael HoaJames M Coticchia
Oct 27, 2020·International Archives of Otorhinolaryngology·Andro KošecTomislav Baudoin

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