Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs

The Journal of Small Animal Practice
A GabrielD Peeters

Abstract

To characterise clinical, electrophysiological and histopathological findings. To analyse pedigree information in six young related Pyrenean mountain dogs with laryngeal paralysis-polyneuropathy complex (LP-PNC). A retrospective study of clinical records and pedigrees of six young related Pyrenean mountain dogs with LP-PNC was carried out. All dogs were presented with laryngeal paralysis and concurrent megaoesophagus. Electrodiagnostic testing was performed in three dogs and showed electrophysiological abnormalities in the distal appendicular muscles. Histopathological findings of peripheral nerve samples were dominated by distal axonal degeneration. Clinical, electrophysiological and histopathological findings were supportive of a diagnosis of degenerative, sensorimotor LP-PNC, similar to that reported in young dalmatians and rottweilers. All dogs died or were euthanased by two years of age. An autosomal recessive mode of inheritance was suspected based on pedigree analysis. Congenital LP-PNC should be suspected in any young dog presenting with laryngeal dysfunction and other concurrent neurological abnormalities. The prognosis is usually poor.

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Citations

Nov 3, 2010·Journal of the American Animal Hospital Association·Brian Thunberg, Gary C Lantz
Jul 9, 2010·Journal of the American Animal Hospital Association·Jeff Weinstein, Debra Weisman
Nov 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Catriona Macphail
Mar 10, 2010·Veterinary Surgery : VS·Bryden J StanleyJennifer Kinns
Sep 27, 2016·American Journal of Veterinary Research·David E HoltPaula S Henthorn
Oct 27, 2016·The Journal of Small Animal Practice·J GanjeiJ Hodgson
May 31, 2013·Journal of the South African Veterinary Association·Adriaan M KitshoffHilde de Rooster
Oct 14, 2018·Journal of Veterinary Internal Medicine·Hélène VandenbergheStéphane Blot
Nov 13, 2019·Journal of the American Animal Hospital Association·Sergio A GomesAn Vanhaesebrouck
Jun 25, 2020·Veterinary Pathology·Hanne JahnsG Diane Shelton
May 5, 2010·Journal of the American Animal Hospital Association·Kelley M ThiemanG Diane Shelton
Nov 6, 2012·The Journal of Veterinary Medical Science·Masaya TsuboiHiroyuki Nakayama
Oct 3, 2018·Journal of the American Veterinary Medical Association·Dirsko J F von PfeilBryden J Stanley

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