Laryngeal sarcomas: A case series of 5 cases

Annals of Diagnostic Pathology
Badr AbdullGaffar, Tasnim Keloth

Abstract

Primary sarcomas of the larynx are rare and miscellaneous. The most common is chondrosarcoma. Other sarcomas are very rare. Sarcomas can have heterogeneous morphologic features of spindle, small round, epithelioid, pleomorphic and giant cells. Laryngeal sarcomas may mimic carcinomas, lymphomas, small cell carcinoma, mesothelioma and melanoma. This imposes diagnostic challenges for unfamiliar pathologists particularly in small laryngeal biopsies. Our aim was to study the different types of sarcomas that can involve the larynx in our institution, to investigate their diagnostic challenges and potential pitfalls and to find helpful histologic clues to avoid misinterpretation and missed diagnosis. We performed a retrospective review study over 13 years. We retrieved 5 cases of laryngeal sarcomas. They included Kaposi sarcoma, low-grade chondrosarcoma, epithelioid angiosarcoma, polypoid leiomyosarcoma and small cell osteosarcoma. The age range was between 32 and 74 years with an average age of 52 years. The male to female ratio was 3:2. The Kaposi sarcoma and chondrosarcoma were correctly diagnosed. The angiosarcoma was initially missed as recurrent carcinoma. The leiomyosarcoma was initially inferred as polypoid sarcomatoid squamou...Continue Reading

Citations

Sep 19, 2019·BMJ Case Reports·Bruno GallettiFrancesco Galletti
Dec 10, 2019·Head and Neck Pathology·Jose G MantillaRobert W Ricciotti
Jul 24, 2020·Oncology and Therapy·Antti A MäkitieAlfio Ferlito
Mar 10, 2021·Head and Neck Pathology·Jaylou M Velez TorresAndrew E Rosenberg
Mar 17, 2021·Head and Neck Pathology·Amin Heidarian, Bruce M Wenig

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