Laryngo-upper esophageal sphincter contractile reflex in humans deteriorates with age

Gastroenterology
Osamu KawamuraReza Shaker

Abstract

Recent studies have shown the existence of several reflex connections between the aerodigestive and upper gastrointestinal tracts. Our aim was to study the effect of laryngeal stimulation on upper esophageal sphincter (UES) pressure and to determine the reproducibility of this effect. We studied 14 young and 10 elderly healthy nonsmoker volunteers and 7 patients with UES dysphagia using a concurrent manometric and video endoscopic technique. Three levels of laryngeal air stimulation were studied: 6 mm Hg/50 ms, 10 mm Hg/50 ms, and 6 mm Hg/2 s. Ten young subjects were studied twice. For 6-mm Hg/2-s and 6-mm Hg/50-ms duration stimuli, the frequency of UES response to air stimulation as evidenced by mucosal deflection (response/deflection ratio) in the elderly volunteers was significantly lower compared with that of young subjects (P < 0.05). The response/deflection ratio of the 6-mm Hg/2-s stimulus was significantly higher than those induced by stimuli of shorter duration (P < 0.01). Poststimulation UES pressure was significantly higher than prestimulation pressure (P < 0.05) in both groups. The magnitude of the increase in poststimulation UES pressure in the elderly volunteers was similar to that of the young subjects. Findings ...Continue Reading

References

Jan 1, 1995·Dysphagia·R Shaker
Jan 9, 1998·The American Journal of Medicine·C T Sasaki, E M Weaver
Jan 9, 1998·The American Journal of Medicine·R Shaker, I M Lang
Sep 17, 1998·The Laryngoscope·S O UlualpR Shaker
Jul 8, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J P NoordzijP A Levine
Aug 25, 2000·Current Gastroenterology Reports·I M Lang, R Shaker
Sep 13, 2000·The Laryngoscope·J RenR Shaker

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Citations

Sep 4, 2010·Dysphagia·Catriona M Steele, Arthur J Miller
Nov 7, 2015·Current Therapeutic Research, Clinical and Experimental·Jeremy FieldsKonrad S Schulze
Aug 13, 2008·Geriatric Nursing·Caryn S Easterling, Elizabeth Robbins
Dec 2, 2014·Clinical and Experimental Otorhinolaryngology·Seckin O Ulualp
Aug 26, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Zhao, H Gregersen
Jan 8, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O KawamuraM Kusano
Feb 16, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K BitarJ W Wiley
Jan 29, 2016·Journal of Pharmaceutical Health Care and Sciences·Manabu SunoYuta Yoshizaki
Jul 19, 2014·Frontiers of Medicine·Zhonggao WangJianjun Liu
Sep 10, 2014·The Journal of Craniofacial Surgery·Ayşe Pelin GörBulent Sam
May 29, 2013·The American Journal of Gastroenterology·Bijo K JohnJames S Scolapio
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lilani PereraReza Shaker
Jul 13, 2006·British Journal of Nursing : BJN·Heather Morris
Aug 21, 2018·Journal of Oral Rehabilitation·Kannit PongpipatpaiboonMarlís G Fernández
Oct 29, 2020·The Laryngoscope·Frederik J MeisollMartin Ptok
Jan 20, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Alexander G Foote, Susan L Thibeault

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