Laryngopharyngeal Reflux and Atypical Gastroesophageal Reflux Disease

Gastrointestinal Endoscopy Clinics of North America
Caroline M BarrettMichael F Vaezi

Abstract

Laryngopharyngeal reflux and atypical manifestations of gastroesophageal reflux disease have a high economic and social burden in the United States. There is increasing research supporting the reflex theory and hypersensitivity syndrome underlying this disease pathophysiology. Novel diagnostic biomarkers have gained more traction in the search for a more reliable diagnostic tool, but further research is needed. Current standard-of-care treatment relies on proton pump inhibitor therapy. Antireflux surgery is usually not recommended. Neuromodulators and treatments targeting specific neuronal receptors are discussed. A diagnostic algorithm is proposed for the evaluation of laryngeal symptoms suspected to be related to extraesophageal reflux disease.

References

Jul 1, 1990·Gastroenterology·R A WrightB F Corsello
Nov 1, 1968·The Laryngoscope·J Cherry, S I Margulies
Sep 25, 2001·The Laryngoscope·P C BelafskyJ A Koufman
May 2, 2002·Gastroenterology·Robert S SandlerRobert Rubin
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael F VaeziJoel E Richter
Feb 22, 2005·Gastrointestinal Endoscopy Clinics of North America·Tasneem Ahmed, Michael F Vaezi
May 18, 2005·The Annals of Otology, Rhinology, and Laryngology·Bryant Lee, Peak Woo
Aug 12, 2005·The Laryngoscope·John KnightJamie A Koufman
Feb 17, 2006·The Laryngoscope·Petros D Karkos, Janet A Wilson
Apr 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jason SwogerMichael F Vaezi
Oct 14, 2006·The American Journal of Gastroenterology·Mohammed A QadeerMichael F Vaezi
May 5, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sander JoniauA Simon Carney
Dec 4, 2008·Pulmonary Pharmacology & Therapeutics·L McGarveyR W Costello
Apr 21, 2009·The Annals of Otology, Rhinology, and Laryngology·Neil N ChhedaGregory N Postma
Apr 28, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Reena Gupta, Robert Thayer Sataloff
May 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·S AyaziT R DeMeester
Jun 9, 2009·The Laryngoscope·George SunMichael F Vaezi
Jun 26, 2009·The Laryngoscope·Stacey L HalumBryan R McRae
May 5, 2010·Cleveland Clinic Journal of Medicine·David W Barry, Michael F Vaezi
Jul 6, 2010·Gastroenterology·Jaclyn A SmithLesley A Houghton
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael FriedmanNinos Joseph
May 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E ChiouS Nurko
Jun 17, 2011·The Annals of Otology, Rhinology, and Laryngology·Jamie A Koufman
Nov 24, 2011·The Laryngoscope·Kenneth C FletcherMichael F Vaezi
Mar 28, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Valentin BeckerMonther Bajbouj
Oct 24, 2012·The American Journal of Gastroenterology·Robert T KavittMichael F Vaezi
Mar 16, 2013·International Journal of Pediatric Otorhinolaryngology·Thomas M Andrews, Nicklas Orobello
Mar 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E S YukselM F Vaezi
Apr 3, 2013·The American Journal of Gastroenterology·David O FrancisMichael F Vaezi
Jun 20, 2013·The Journal of Allergy and Clinical Immunology·Emma C Y HiltonJaclyn A Smith
Sep 30, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David O Francis, Michael F Vaezi
Dec 3, 2014·Gastroenterology·Fehmi AtesMichael F Vaezi
Dec 3, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Frank Zerbib

❮ Previous
Next ❯

Citations

Jul 22, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ya-Lian ChenZhe Chen
Jul 11, 2020·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Gül B Makal, Ahmet G Türkçapar
Apr 22, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hee Jin KangSeong-Gyu Ko
Jul 24, 2021·Revista de gastroenterología de México·L SoiferUNKNOWN grupo de colaboración de ERGE de la Sociedad Latinoamericana de Neurogastroenterología

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Advances in Chronic Disease
Irene MartinucciSantino Marchi
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Vui Heng Chong
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
J J HuH Yang
Current Opinion in Otolaryngology & Head and Neck Surgery
Venu Divi, Michael S Benninger
Current Opinion in Otolaryngology & Head and Neck Surgery
Michiel J Bove, Clark Rosen
© 2021 Meta ULC. All rights reserved