PMID: 4289294Mar 1, 1967Paper

Laryngotracheitis virus in chickens. A model for study of acute nonfatal desquamating rhinitis

The Journal of Experimental Medicine
B G Bang, F B Bang

Abstract

Infectious laryngotracheitis can be produced in chickens as an experimental model of severe nonfatal rhinitis and sinusitis. Inoculated intranasally into unanesthetized baby chicks it remains limited to the nasal fossa, produces acute desquamation of all nasal epithelia, results in functional recovery of the respiratory epithelium, but leaves important residual abnormalities. From the earliest recognizable lesions through 4(1/2) months' convalescence, the principal changes are as follows: 1. Initial lesions, or small syncytia of intranuclear "inclusions", first identifiable in the mucociliated cells of the shallowest portion of the epithelium at about 21 hr postinoculum (the inner surface of the maxillary conchal scroll). 2. Acute sloughing, (about 3 to 7 days), marked by: (a) spread of lesions from cell to cell via multinucleated "giant cells" which progressively slough and desquamate respiratory, olfactory, and sinus epithelia, epithelial neural elements and blood vessels; (b) appearance of numbers of eosinophilic leukocytes along the basement membrane at the sites of lesions just previous to sloughing; intensive infiltration of the submucosa with small lymphocytes after sloughing begins; (c) histochemical change in the intra...Continue Reading

References

May 1, 1960·The Journal of Experimental Medicine·L THOMASG WEISSMANN
Feb 14, 1964·Science·C GROBSTEIN
Jan 1, 1964·Acta Anatomica·B G BANG

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Citations

May 1, 1977·Archives of Environmental Health·M WakabayashiF B Bang
Mar 1, 1981·Australian Veterinary Journal·G M Robertson, J R Egerton
Aug 22, 2014·Avian Pathology : Journal of the W.V.P.A·Vishwanatha R A P ReddyHans J Nauwynck
Jun 1, 1970·The Annals of Otology, Rhinology, and Laryngology·F B Bang, B G Bang
Mar 1, 1973·The Annals of Otology, Rhinology, and Laryngology·Y SasakiD F Proctor
Jun 1, 1993·The Annals of Otology, Rhinology, and Laryngology·K ForsgrenB Carlsöö

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