LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.

Genetics
A I Doseff, K T Arndt

Abstract

Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss of LAS1 function causes the cells to arrest as 80% unbudded cells and 20% large budded cells that accumulate many vesicles at the mother-daughter neck. Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud. The nuclear localization of LAS1 suggests a role of LAS1 for regulating bud formation and morphogenesis via the expression of components that function directly in these processes.

Citations

Nov 16, 2011·Molecular and Cellular Biology·Stéphanie SchillewaertDenis L J Lafontaine
Sep 5, 2002·Yeast·Anne G RosenwaldRichard A Kahn
Sep 7, 2004·The Journal of Biological Chemistry·J Marcela HernandezErich Grotewold
Jul 6, 2020·Nature Communications·Cristina Maria Osuna-CruzKlaas Vandepoele
Mar 22, 2008·Molecular Genetics and Genomics : MGG·H Reynaldo López-MirabalMorten C Kielland-Brandt
Apr 1, 2008·FEMS Yeast Research·Layla F MartinsLucia Mendonça-Previato
Jun 25, 2002·The Journal of Biological Chemistry·Maria Angeles de la Torre-RuizEnrique Herrero
Aug 13, 2002·The Journal of Biological Chemistry·Jordi TorresMaria Angeles De La Torre-Ruiz
Jul 22, 2010·Molecular and Cellular Biology·Christopher D CastleCatherine Denicourt
Mar 10, 2011·The Journal of Biological Chemistry·Erina KitanoJun-ichi Nakayama
Oct 22, 2008·Molecular and Cellular Biology·Snober S MirAnil G Cashikar

❮ Previous
Next ❯

Related Concepts

Related Feeds