Abstract
The HeartLight laser balloon ablation system was US Food and Drug Administration approved in 2016 for the treatment of paroxysmal atrial fibrillation (AF), but there have been numerous single-center and multicenter studies published reporting its outcomes, in addition to a few randomized trials. We aimed to systematically review and synthesize currently published outcome data on AF ablation using the laser balloon ablation system. We performed a systematic review and meta-analysis of published studies of AF ablation performed using the laser balloon ablation system. Human studies reporting acute procedural results with a minimum of 6 months follow-up were included. Outcomes of interest included acute and 12-month procedural efficacy, safety, and procedure duration. Aggregated data were analyzed with random effects models, using a Bayesian hierarchical approach. We identified 17 published manuscripts comprising a sample of 1188 patients (mean age 61 years, 80% paroxysmal). At procedure end, 98.8% of targeted pulmonary veins were successfully isolated. The pooled estimate for 12-month freedom from atrial arrhythmia without use of antiarrhythmic drugs for patients with paroxysmal AF was 74.3% (95% confidence interval [CI], 59.9% t...Continue Reading
References
Aug 3, 2005·Circulation·Atul VermaAndrea Natale
Jun 24, 2009·Circulation·Vivek Y ReddyAndrea Natale
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 25, 2009·Statistics in Medicine·David LunnNicky Best
Jan 28, 2010·JAMA : the Journal of the American Medical Association·David J WilberUNKNOWN ThermoCool AF Trial Investigators
Mar 19, 2013·Journal of the American College of Cardiology·Douglas L PackerUNKNOWN STOP AF Cryoablation Investigators
Jul 18, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Lucie ŠediváPetr Neužil
Jul 30, 2014·Journal of Cardiovascular Electrophysiology·Laura PerrottaBoris Schmidt
Aug 16, 2014·Journal of the American College of Cardiology·Andrea NataleFrancis E Marchlinski
May 7, 2015·The New England Journal of Medicine·Atul VermaUNKNOWN STAR AF II Investigators
Jun 17, 2015·Journal of Cardiovascular Electrophysiology·Srinivas R DukkipatiVivek Y Reddy
Aug 12, 2015·Circulation·Vivek Y ReddyMoussa Mansour
Sep 19, 2015·Journal of the American College of Cardiology·Srinivas R DukkipatiUNKNOWN HeartLight Study Investigators
Apr 5, 2016·The New England Journal of Medicine·Karl-Heinz KuckUNKNOWN FIRE AND ICE Investigators
Aug 4, 2016·Pacing and Clinical Electrophysiology : PACE·Florian StöckigtJan W Schrickel
Dec 17, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Laura PerrottaBoris Schmidt
Oct 11, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hugh CalkinsUNKNOWN Document Reviewers:
Dec 9, 2017·Circulation. Arrhythmia and Electrophysiology·Boris SchmidtK R Julian Chun
Citations
Sep 8, 2019·Lasers in Surgery and Medicine·Suhyun ParkHyun Wook Kang
Apr 24, 2020·Journal of Cardiovascular Electrophysiology·Fabrizio R AssisHarikrishna Tandri
Oct 22, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yue WeiLiqun Wu
Feb 5, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinichi TachibanaTetsuo Sasano
Oct 23, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas J BuistArif Elvan
Mar 7, 2021·Micromachines·Jamario R SkeeteHenry D Huang
May 27, 2020·Cardiac Electrophysiology Clinics·Rahul BhardwajSrinivas R Dukkipati
May 11, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuharu Matsunaga-LeeJun Tanouchi
Oct 8, 2021·Expert Review of Medical Devices·Shota TohokuBoris Schmidt