Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection

Neurosurgical Review
A A PotapovA Spallone

Abstract

5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly gliomas, has gained popularity in the last years, whereas its use in other intracranial pathological entities including meningiomas has been reported occasionally. This study describes a series of 28 patients with intracranial meningiomas, who were administered 5-ALA for a better visualization of tumor boundaries. Twelve patients underwent also laser spectroscopic analysis in order to confirm the visual impression of tumor tissue visualization. Bone infiltration was readily demonstrated. In one case, the tumor recurrence could have been prevented by removal of a tumor remnant, which would possibly have been better recognized if spectroscopic analysis had been used. Fluorescent navigation (FN) is a useful method for maximizing the radicality of meningioma surgery, particularly if the tumor infiltrates the bone, the skull base, and/or the surrounding structures.

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Citations

May 29, 2016·Photodiagnosis and Photodynamic Therapy·Naomi Foster, Sam Eljamel
Mar 23, 2019·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A PotapovG V Danilov
Jul 30, 2019·Journal of Neurosurgical Sciences·Andrea Boschi, Alessandro Della Puppa
Dec 25, 2019·Acta neurochirurgica·Florian ScheichelFranz Marhold
Feb 8, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A PotapovV P Chekhonin
Feb 6, 2017·The Review of Scientific Instruments·Nikita V ChernomyrdinKirill I Zaytsev
May 26, 2018·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A PotapovV B Loshchenov
Nov 30, 2018·Journal of Neuro-oncology·Jan Coburger, Christian Rainer Wirtz
Sep 26, 2019·Frontiers in Oncology·Sergey A GoryaynovAlexandr A Potapov
Jun 20, 2018·Operative Neurosurgery·David W RobertsKeith D Paulsen
Dec 7, 2018·Neurosurgical Review·Bianca M DijkstraRob J M Groen
Nov 7, 2019·Brain Tumor Research and Treatment·So Young JiChul Kee Park
Jan 4, 2019·Journal of Neuro-oncology·Pablo A ValdesDavid W Roberts
Dec 18, 2021·Lasers in Surgery and Medicine·Irina N DolganovaVladimir N Kurlov
Apr 26, 2018··Kirill I. ZaytsevPolina V. Aleksandrova
Apr 26, 2018··Gennadiy A. KomandinNikita V. Chernomyrdin
Jul 28, 2017··Irina A. ShikunovaKonstantin G. Kudrin
Jul 23, 2019··Kirill I. ZaytsevNikita V. Chernomyrdin

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