Laser Desorption Combined with Laser Postionization for Mass Spectrometry

Annual Review of Analytical Chemistry
Luke HanleyYeni P Yung

Abstract

Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral resolution, decoupling of ionization from desorption, improved analysis of electrically insulating samples, and potential for high sensitivity and depth profiling while minimizing differential detection. A description of postionization by vacuum UV radiation is followed by a consideration of multiphoton, short pulse, and other postionization strategies. The impacts of laser pulse length and wavelength are considered for laser desorption or laser ablation at low pressures. Atomic and molecular analysis via direct laser desorption/ionization using near-infrared ultrashort pulses is described. Finally, the postionization of clusters, the role of gaseous collisions, sampling at ambient pressure, atmospheric pressure photoionization, and the addition of UV postionization to MALDI are considered.

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Citations

Nov 11, 2020·Mass Spectrometry Reviews·Vladimir A AzovAlexander A Makarov
Mar 30, 2021·Journal of the American Society for Mass Spectrometry·Eike U BrockmannKlaus Dreisewerd
Aug 5, 2021·Analytical Chemistry·Shane L McPhersonKatharine Moore Tibbetts
Jul 17, 2020·Journal of the American Society for Mass Spectrometry·Alexander PotthoffJens Soltwisch
Feb 8, 2020·Journal of the American Society for Mass Spectrometry·Sven HeilesBernhard Spengler
Sep 23, 2020·The Journal of Physical Chemistry Letters·Cornelius L PieterseLuke Hanley
Sep 14, 2021·Journal of the American Society for Mass Spectrometry·Josiah C McMillenRichard M Caprioli
Jan 12, 2022·Journal of the American Society for Mass Spectrometry·Alexander PotthoffJens Soltwisch

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Methods Mentioned

BETA
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PIRL
Ns
fs
LD
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