PMID: 8965324Mar 1, 1996Paper

Laser-Doppler flowmetry measurements of subcortical blood flow changes after fluid percussion brain injury in rats

Journal of Neurotrauma
J B LongS L Bolt

Abstract

Laser-Doppler flowmetry (LDF) was used to record subcortical cerebral blood flow in hippocampus and striatum immediately following parasaggital fluid percussion brain injuries of mild to moderate severity (2.58 +/- 0.09 atm, 10-11 msec duration) in spontaneously breathing anesthetized rats. At 5 min postinjury, mean blood flow decreased bilaterally by 20-30% in both brain structures, and remained significantly reduced during the remainder of the 60 min postinjury recording interval. Blood flow did not change in the sham-injured rats. Subsequent beam-walk, beam-balance, and rope-hang assessments revealed significant neurological impairments in the injured rats but not in the sham controls. The magnitude of the blood flow changes and the severity of the ensuing neurological impairment were significantly correlated. Histopathological assessments revealed hemorrhagic contusions within ipsilateral cortical regions, occasional neuronal necrosis within underlying thalamus and CA3 and CA4 sectors of the hippocampus, and neuronal cell loss in the hilus of the dentate gyrus. In a second series of experiments, radiolabeled microspheres were used to validate the LDF blood flow measurements. The microsphere measurements revealed that the pr...Continue Reading

References

Dec 1, 1978·Journal of the Neurological Sciences·D I GrahamD Doyle
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jan 1, 1992·Journal of Neurotrauma·H A Kontos, E P Wei
Feb 1, 1992·Molecular and Chemical Neuropathology·D C PerryR L Hayes
Jan 1, 1992·Journal of Neurotrauma·S S PanterE D Hall
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M JacewiczW A Pulsinelli
Jan 1, 1991·Journal of Neurotrauma·H GoldmanS Murphy
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Mar 1, 1991·Journal of Neurosurgery·D W MarionH Yonas
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Yamakami, T K McIntosh
Feb 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Yamakami, T K McIntosh
Mar 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D I GrahamD R McLellan
Jan 1, 1988·Journal of Neurotrauma·X Q YuanD S Dewitt
Apr 1, 1988·Journal of Neurosurgery·A W UnterbergA Marmarou
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N IshigeP R Weinstein
Jan 1, 1985·British Journal of Anaesthesia·J D Miller
Jan 1, 1985·British Journal of Anaesthesia·L Symon
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Jan 1, 1984·Acta Neuropathologica·T Kirino, K Sano
Jun 1, 1981·Journal of Neurosurgery·T H JonesR G Ojemann
Apr 1, 1995·Journal of Neurotrauma·J K MuirE F Ellis
Apr 1, 1995·Anesthesia and Analgesia·R M BryanC Robertson
Apr 1, 1994·Journal of Neurotrauma·P D GrundlE M Nemoto

❮ Previous
Next ❯

Citations

Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Jan 11, 2013·Journal of Neurotrauma·Michael J HylinPramod K Dash
Sep 3, 2004·Neuroscience and Biobehavioral Reviews·Scott T FujimotoTracy K McIntosh
Dec 2, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Naoki OtaniKatsuji Shima
Mar 25, 2015·Journal of Neuroscience Methods·Radia Abdul WahabBryan J Pfister
Oct 19, 2016·Journal of Neurotrauma·Stacy L SellDonald S Prough
Jul 14, 2001·Acta Neurochirurgica. Supplement·Y MatsushitaT Miyazawa
Apr 23, 2008·Current Protocols in Neuroscience·Geoffrey S F LingAudrey N Kalehua
May 27, 2020·PloS One·Katherine A RuppertScott D Olson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.