PMID: 8941679Dec 1, 1996Paper

Laser Doppler perfusion imaging of skin blood flow using red and near-infrared sources

The Journal of Investigative Dermatology
N C AbbotJ G Lowe

Abstract

At present, scanning laser Doppler imaging uses a 633-nm helium-neon laser (RED) as the only light source, but this restricts its ability to measure blood flow (i) at darkly pigmented skin and (ii) from deeper or subdermal structures. Because near-infrared (NIR) light is known to penetrate deeper into tissue and to be less absorbed than RED, two imagers were adapted to include a NIR laser diode source (one of 830 nm for UK studies; one of 780 nm for leprosy field trials) in parallel with the existing RED source. In human hands representing a range of skin pigmentations, RED scans were unobtainable at the darkest areas of skin, but intact NIR scans could be collected in all cases. In experiments at the rat knee and the dorsal human hand, NIR and RED values were similar on normal skin. Over underlying vessels, however, NIR values greatly exceeded RED values, an effect abolished by occlusion. Similarly, in patients with leprosy and in healthy controls in Spain, fingerpulp NIR values exceeded RED values to the greatest degree when thermoregulatory flow was highest, i.e., when the deeper-lying arteriovenous anastomoses were open. Over areas of experimental inflammation, NIR gave higher values and also exhibited a greater degree of s...Continue Reading

Citations

Apr 24, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Rikke Kragh LauridsenLars Nørgaard
Apr 2, 2010·American Journal of Physical Medicine & Rehabilitation·Oscar U ScreminMark Mandelkern
Mar 7, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Brook A FultonClaudia M Campbell
Jan 20, 1999·Journal of Clinical Laser Medicine & Surgery
Apr 9, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J AdolphsM Schafer
Nov 7, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Hyung Sub ParkTaeseung Lee
Apr 19, 2019·Physiological Measurement·Miriam van der HoekNienke Bosschaart
Apr 7, 2007·American Journal of Physical Medicine & Rehabilitation·Charles F KunkelA M Erika Scremin
Jan 11, 2016·Lasers in Surgery and Medicine·Qingliang LiuBo Chen
Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ahmad Y SheikhThomas K Hunt

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