PMID: 9525247Apr 3, 1998Paper

Laser-induced fluorescence imaging in localization of head and neck cancers

The Annals of Otology, Rhinology, and Laryngology
B Kulapaditharom, V Boonkitticharoen

Abstract

Laser-induced fluorescence tumor imaging exploits the difference in tissue autofluorescence properties between normal and cancerous tissues. The effectiveness and reliability of fluorescence imaging with a lung imaging fluorescence endoscopy (LIFE) system for cancers in the head and neck were compared to those of white light endoscopy (WLE). Examinations by WLE and LIFE were conducted on 25 patients suspected for malignancy. Histologic diagnosis was confirmed by biopsy. Posttreatment evaluations were performed on 6 cancer patients identified by this study. By LIFE, all 16 cancerous lesions, including 2 occult cancers, were identified (100%), while WLE achieved only an 87.5% detection rate. LIFE (specificity 87.5%) was greatly helpful to WLE (specificity 50%) in differentiating inflammation from malignancy, though it failed to exclude granuloma. The results of this study suggest potential roles of LIFE in early detection, correct staging, and treatment evaluation of cancers in the head and neck.

References

Jan 1, 1991·Lasers in Surgery and Medicine·J HungB Palcic
Jan 1, 1982·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·O J BalchumG C Huth
Feb 1, 1995·The Journal of Laryngology and Otology·M L HarriesB Palcic

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Citations

Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·Petra Wilder Smith
Jan 8, 2003·Lasers in Surgery and Medicine·Arata EbiharaPetra Wilder-Smith
Aug 6, 1999·The Annals of Otology, Rhinology, and Laryngology·B KulapaditharomS Kunachak
Dec 1, 2004·Journal of Biomedical Optics·A L ClarkR Richards-Kortum
Jun 11, 2004·Journal of Biomedical Optics·Stavros G DemosRalph deVere White
May 10, 2008·Journal of Biomedical Optics·Darren RoblyerAnn M Gillenwater
May 30, 2015·The Cochrane Database of Systematic Reviews·Richard MaceyCrispian Scully
Jul 27, 2000·Photochemistry and Photobiology·D L HeintzelmanR R Richards-Kortum
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Christian S BetzAndreas Leunig
Nov 19, 2005·Journal of Biomedical Optics·Petra Wilder-SmithBruce Tromberg
Mar 2, 2006·Current Oncology Reports·Ann GillenwaterRebecca Richards-Kortum
Feb 24, 2001·The Annals of Otology, Rhinology, and Laryngology·B Kulapaditharom, V Boonkitticharoen
Apr 30, 2009·Cancer Prevention Research·Darren RoblyerRebecca Richards-Kortum
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·N Ramanujam
Feb 17, 2001·Gastroenterology·P R Pfau, M V Sivak
Jul 21, 2021·The Cochrane Database of Systematic Reviews·Tanya WalshSaman Warnakulasuriya

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