Laser-induced thermal desorption facilitates postsource decay of peptide ions.

Journal of the American Society for Mass Spectrometry
Shin Hye KimSang Yun Han

Abstract

We investigated the thermal mechanism involved in laser desorption/ionization (LDI) of thermally labile molecules from the flat surfaces of amorphous Si (a-Si) and crystalline Si (c-Si). a-Si was selected for this study because of its thermal property, such as low thermal conductivity; thus, it was predicted to be highly susceptible to laser-induced surface heating. By virtue of lack of surface nanostructures, the flat surfaces offer a simple model system to focus on the thermal mechanism, avoiding other effects, including possible non-thermal contributions that can arise from the physical existence of surface nanostructures. For the energetics study, the internal energies of substituted benzylpyridinium ions produced by LDI on the bare and coated surfaces of a-Si and c-Si were obtained using the survival yield method. The results, including LDI thresholds, ion yields, and internal energies all suggested that the LDI mechanism would be indeed thermal, which is most likely promoted by thermal desorption caused by laser-induced surface heating. In addition, the LDI process driven by laser-induced thermal desorption (LITD) was also found to be capable of depositing an excessive internal energy in resulting LDI ions, which underwen...Continue Reading

References

Jan 4, 2003·Analytical Chemistry·Guanghong LuoAkos Vertes
Jun 28, 2003·Analytical and Bioanalytical Chemistry·Detlev SuckauArmin Holle
Mar 15, 2005·Analytical Chemistry·E P GoG Siuzdak
Dec 27, 2005·The Journal of Physical Chemistry. B·Guanghong LuoAkos Vertes
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Oct 26, 2007·Nature·Trent R NorthenGary Siuzdak
May 21, 2008·Analytical Chemistry·Nien-Yeen HsuChung-Hsuan Chen
Jan 27, 2009·Angewandte Chemie·Bennett N WalkerAkos Vertes
Jan 14, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Gaëlle PiretRabah Boukherroub
Mar 9, 2010·Journal of the American Society for Mass Spectrometry·Won Jik ShinSang Yun Han

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Citations

Oct 12, 2012·Analytical and Bioanalytical Chemistry·Chhavi BhardwajLuke Hanley
Dec 20, 2012·Journal of the American Society for Mass Spectrometry·Shin Hye KimSang Yun Han

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