PMID: 2500827Jan 1, 1989Paper

Laser micro-spectroanalytical determinations of aluminum in lumbar vertebrae of non-nephrectomized and 5/6 nephrectomized rats after application of dose- and time-dependent aluminum chloride solutions

Acta histochemica
R SchmidtD Günther

Abstract

In order to obtain further informations on the mode of action of Al, we carried out lasermicroanalytical determinations (LMA) of Aluminium (Al) on different parts of lumbar vertebrae in 54 non-nephrectomized rats and 54 ones 5/6 nephrectomized which were divided in 3 groups. The animals were treated with solutions of physiological NaCl in the control group (0.25 ml/100 g b.w.) and different Al-doses (0.05 and 0.5 mg/kg b.w.) intraperitoneally and daily for 4, 8, and 12 weeks. The results were compared with those of histochemical Al-detections by the method of IRWIN (1955). Lumbar vertebrae of the non-nephrectomized rats in the control group did not contain Al by LMA- and histochemical determination investigated in all the time intervals. Al-doses of 0.05 mg/100 g b.w. induced only a positive Al-proof 12 weeks after the beginning of the injections in the 5/6 nephrectomized animals by LMA, whereas Al-doses 10 times higher effected an Al-deposit of different concentration in the substance compact and substance spongioid of the lumbar body of vertebrae from the 4th week in the 5/6 nephrectomized and the 8th in the non-nephrectomized rats. The sensitiveness of the Al-detection by LMA was higher in comparison with the histochemical p...Continue Reading

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