Laser microprobe mass spectrometry of platinum in dog kidney after cisplatin administration

Biomedical Mass Spectrometry
A H VerbuekenM E De Broe

Abstract

By means of laser microprobe mass analysis ( LAMMA ) platinum was detected in the renal proximal tubular cells of a dog that had been intravenously administered the antitumor drug cisplatin (5 mg per kg body weight). No definite subcellular localization of the heavy metal was obtained. Sample preparation and analytical features are examined to increase spatial resolution of analysis while maintaining sufficient detection efficiency. The LAMMA method is destructive, but the amount and type of evaporated material can readily be determined when using LAMMA in combination with transmission electron microscopy. Instrumental optimization and standardization of mass signals is possible by using platinum-loaded, ion-chelating resin beads embedded and sectioned with the tissue.

References

Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·D LehaneY Daskal
Jun 1, 1978·Chemico-biological Interactions·M U Khan, P J Sadler
Mar 1, 1976·Journal of Pharmaceutical Sciences·F K Leh, W Wolf
Sep 15, 1980·Toxicology and Applied Pharmacology·D D ChoieA M Guarino

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Citations

Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·A H VerbuekenR Van Grieken
Sep 1, 1985·Biomedical Mass Spectrometry·A H VerbuekenR E Van Grieken
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·Y IchikawaS Nagano
Jan 27, 2012·Clinical Reviews in Allergy & Immunology·Fatih Gultekin, Duygu Kumbul Doguc

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