PMID: 6106507Aug 21, 1980Paper

Laser Raman studies on the conformation of Pro-Leu-Gly-NH2

Biochimica Et Biophysica Acta
T H Hseu, H Chang

Abstract

Laser Raman spectra of Pro-Leu-Gly-NH2, the factor that inhibits release of pituitary melanotropin, have been obtained in the solid state, in dimethylsuloxide and in aqueous solution. The amide I frequencies were observed at 1650 and 1687 cm-1 in the solid state and at 1669 cm-1 in dimethylsulfoxide. The conformation of this tripeptide has been proposed by 1H-NMR studies in [2H]-dimethylsulfoxide and revealed by X-ray analysis to be type II beta-turn. These observed amide I frequencies thus are characteristic of type II beta-turn conformation. The relatively lower amide I frequency, 1645 cm-1, observed in 2H2O indicates that the conformation of the peptide in aqueous solution could be different from those in solid state and in dimethylsulfoxide. pH changes hae no significant effect on aqueous solution spectra, except for the shape of the amide III band. The maximum of the amide III band shifted from 1259 cm-1 at pH 2.0 to 1242 cm-1 at pH 11.7. The amide III peaks in the solid state were at 1234 and 1268 cm-1.

References

Dec 20, 1978·Biochimica Et Biophysica Acta·T H HseuC C Yang
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R DeslauriersJ W Van Nispen
Sep 15, 1977·Journal of Molecular Biology·P Y Chou, G D Fasman
Apr 26, 1978·Biochimica Et Biophysica Acta·A T TuV J Hruby
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Kang, R Walter
Jun 18, 1971·Biochemical and Biophysical Research Communications·R M NairA V Schally
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E RalstonR Walter
Oct 31, 1973·Journal of the American Chemical Society·L L Reed, P L Johnson
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M E CelisR Walter
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J Bandekar, S Krimm

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Citations

Mar 1, 1994·Protein Science : a Publication of the Protein Society·Z Q WenL D Barron
Mar 1, 1982·Peptides·J W FoxJ M Stewart
Oct 15, 1981·Archives of Biochemistry and Biophysics·J A FoxH I Mosberg
Feb 15, 1984·European Journal of Biochemistry·P LagantM H Loucheux-Lefebvre
Feb 15, 1984·European Journal of Biochemistry·P LagantM H Loucheux-Lefebvre
Mar 1, 1989·International Journal of Peptide and Protein Research·G ValleR L Johnson

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