Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Cenk AyataMichael A Moskowitz

Abstract

Laser speckle flowmetry (LSF) is useful to assess noninvasively two-dimensional cerebral blood flow (CBF) with high temporal and spatial resolution. The authors show that LSF can image the spatiotemporal dynamics of CBF changes in mice through an intact skull. When measured by LSF, peak CBF increases during whisker stimulation closely correlated with simultaneous laser-Doppler flowmetry (LDF) measurements, and were greater within the branches of the middle cerebral artery supplying barrel cortex than within barrel cortex capillary bed itself. When LSF was used to study the response to inhaled CO2 (5%), the flow increase was similar to the response reported using LDF. For the upper and lower limits of autoregulation, mean arterial pressure values were 110 and 40 mm Hg, respectively. They also show a linear relationship between absolute resting CBF, as determined by [C]iodoamphetamine technique, and 1/tau(c) values obtained using LSF, and used 1/tau(c) values to compare resting CBF between different animals. Finally, the authors studied CBF changes after distal middle cerebral artery ligation, and developed a model to investigate the spatial distribution and hemodynamics of moderate to severely ischemic cortex. In summary, LSF ha...Continue Reading

References

Jan 1, 1978·Stroke; a Journal of Cerebral Circulation·R L Van Uitert, D E Levy
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A L Betz, F Iannotti
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U Müller, J Krieglstein
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T DalkaraM A Moskowitz
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S B CoxC M Rovainen
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C AyataM A Moskowitz
Jan 1, 1997·Acta Physiologica Scandinavica·P KimmeF Sjöberg
Sep 26, 1997·Stroke; a Journal of Cerebral Circulation·M FujiiM A Moskowitz
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M YamadaM A Moskowitz
Dec 29, 2000·Physics in Medicine and Biology·M KohlU Dirnagl
Jan 9, 2001·Journal of Vascular Research·A N NielsenM Lauritzen
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J GotohL Sokoloff
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A K DunnD A Boas
Feb 1, 2002·Nature Medicine·Hayrunnisa BolayMichael A Moskowitz
Jun 15, 1981·Applied Optics·R Bonner, R Nossal
Jan 1, 1999·Journal of Biomedical Optics·J D BriersX W He

❮ Previous
Next ❯

Citations

Aug 11, 2010·Pflügers Archiv : European journal of physiology·Dmitriy N Atochin, Paul L Huang
Feb 19, 2011·Annals of Biomedical Engineering·Alexander J LinBruce J Tromberg
Nov 24, 2011·Annals of Biomedical Engineering·Andrew K Dunn
Mar 23, 2011·The Journal of Physiological Sciences : JPS·Harumi HottaNaoki Maruyama
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joseph F Arboleda-VelasquezSpyros Artavanis-Tsakonas
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Margaret T ButkoRoger Y Tsien
Nov 5, 2010·Physics in Medicine and Biology·J C Ramírez-San-JuanB Choi
Feb 3, 2005·Photomedicine and Laser Surgery
Mar 23, 2005·Photomedicine and Laser Surgery
Jan 5, 2011·Journal of Biomedical Optics·Ashwin B ParthasarathyAndrew K Dunn
Jun 29, 2012·Journal of Vascular Research·Akos Koller, Peter Toth
Dec 7, 2011·Circulation·Katharina Eikermann-HaerterCenk Ayata
Mar 15, 2008·Stroke; a Journal of Cerebral Circulation·Hwa Kyoung ShinCenk Ayata
Jun 9, 2007·The Journal of Clinical Investigation·Dmitriy N AtochinPaul L Huang
Apr 30, 2013·Journal of Neuroengineering and Rehabilitation·Pengyue ZhangYongshan Hu
Jun 19, 2014·PloS One·Yorito HattoriMasafumi Ihara
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Christopher RisherSergei A Kirov
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R Anne StetlerJun Chen
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katharina Eikermann-HaerterCenk Ayata
Oct 3, 2009·Neurosurgical Focus·Nils HechtPeter Vajkoczy
May 5, 2007·Journal of Biomedical Optics·Michael AtlanMichel Gross
Nov 13, 2007·Journal of Biomedical Optics·Elizabeth M C Hillman
Jun 7, 2011·Journal of Biomedical Optics·Abhishek RegeNitish V Thakor
Dec 17, 2008·Optics Letters·Sean J KirkpatrickElaine M Wells-Gray
Feb 18, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hulya KaratasTurgay Dalkara
Mar 11, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yutaka TomitaElisabeth Pinard
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna DevorDavid A Boas

❮ Previous
Next ❯

Methods Mentioned

BETA
light scattering
blood draws
scintillation spectrometry

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Andrew K DunnDavid A Boas
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Turgut DurduranJoel H Greenberg
© 2022 Meta ULC. All rights reserved