PMID: 2498484Apr 1, 1989Paper

Laser time-resolved fluorescence study of the interaction between anthracyclines and cardiolipin

Journal of Photochemistry and Photobiology. B, Biology
V Malatesta, A Andreoni

Abstract

The molecular interaction between cardiolipin vesicles and two representative anthracyclines, daunomycin and 5-iminodaunomycin, has been studied at pH 7.1 by laser time-resolved fluorescence, for a cardiolipin-to-anthracycline ratio r ranging from 0.02 to 5. The fluorescence lifetime of daunomycin is 1.03 ns. For r = 0.3 - 5 a longer-lived transient (1.91 - 1.49 ns) is present and originates from the excitation of daunomycin bound on a single phosphate group of cardiolipin. At r = 0.3 two lifetimes are observed, the second one being due, partially, to free daunomycin and bound drug molecules embedded in the lipid bilayer. The fastest-decaying species is present for r = 0.5 - 2.0 and identified as two adjacent, stacked-up daunomycin molecules bound onto the two phosphate groups of the cardiolipin. In the case of 5-iminodaunomycin, a less cardiotoxic analogue, three-exponential decay is never observed and a fast-decaying component, pi approximately 0.2 ns, is already present at low r and vanishes for r greater than 0.5. The constancy of the lifetimes of the longer-lived species may originate from the reorientation of the bound drug from the hydrophilic to the lipid domain.

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Citations

Jan 1, 1994·Journal of Biochemical and Biophysical Methods·A AndreoniG Roberti
Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·A AndreoniG Roberti
Feb 24, 1989·Biochimica Et Biophysica Acta·A AndreoniT G Truscott
Jun 1, 1991·Photochemistry and Photobiology·A AndreoniG Roberti

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