LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway

Cancer Letters
ZhiZhen LiYing-Bin Liu

Abstract

LASP-1 is an actin-binding protein that regulates cytoskeletal dynamics and cell migration. LASP-1 was previously identified in a cDNA library from metastatic breast cancer samples. This protein has since been detected in multiple human cancers, including liver cancer, gastric cancer and pancreatic cancer. S100P is a small calcium-binding protein in the S100 protein family that regulates cellular, physiological and pathological processes in various cancers. However, the clinical significance of LASP-1 and S100P expression in gallbladder cancer (GBC) is not yet clear. In our study, we focused on the clinical significance, biological function and mechanism of LASP-1 in gallbladder cancer and detected LASP-1 and S100P overexpression in GBC tissues. The expression of LASP-1 was significantly correlated with poor prognosis in GBC patients (P < 0.05). Furthermore, down-regulation of LASP-1 expression resulted in the obvious inhibition of proliferation and migration and caused cell cycle arrest by down-regulating S100P via the PI3K/AKT pathway; in mice, tumor volume was significantly decreased. In conclusion, LASP-1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in GBC. LASP-1 could serve as...Continue Reading

References

Nov 18, 2003·The Journal of Biological Chemistry·Thiruvengadam ArumugamCraig D Logsdon
Jun 26, 2007·Diseases of the Colon and Rectum·Maren K FuentesEmina H Huang
Jul 31, 2007·The Plant Journal : for Cell and Molecular Biology·W Brad BarbazukPatrick S Schnable
Aug 30, 2008·The Journal of Biological Chemistry·Judith AustermannVolker Gerke
Feb 16, 2010·Amino Acids·Adriana GibadulinovaSilvia Pastorekova
Apr 27, 2010·PloS One·Dayanidhi RamanAnn Richmond
Oct 7, 2010·Cancer Research·Christopher TraenkaStefan M Pfister
Apr 7, 2012·Urologic Oncology·Peter ArdeltElke Butt
Jun 26, 2012·BMC Genomics·José BlancaBelén Picó
Oct 23, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hui WangLiang Zhao
Jul 6, 2014·Journal of Cancer Research and Clinical Oncology·Jie ZhengShijun Lu
Sep 26, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hui WangLiang Zhao
Nov 12, 2014·Cancer Research·Tiansuo ZhaoJihui Hao
Mar 12, 2015·International Journal of Oncology·Alessandro SalviGiuseppina De Petro

❮ Previous
Next ❯

Citations

Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vitalba RuggieriDomenica Mangieri
Mar 31, 2018·Journal of Cellular Physiology·Hongjuan YouRenxian Tang
Aug 7, 2018·Journal of Cellular and Molecular Medicine·Changming WangQingping Cai
Oct 30, 2018·Journal of Cellular Physiology·Jayaramayya KaavyaVellingiri Balachandar
Apr 27, 2019·Journal of Cellular Biochemistry·Yimeng Zhang, Liya Zhang
Jan 11, 2017·Cancer Cell International·Xiao-Ling SongJun Gu
Oct 10, 2018·Frontiers in Oncology·Elke Butt, Dayanidhi Raman
Aug 18, 2020·Biological Trace Element Research·Xi SunHaifeng Shi
Nov 1, 2017·Oncology Letters·Misaki SatoShigeru Tsuboi
Jul 17, 2020·Disease Markers·Xiaojing YangJie Fu
Oct 9, 2020·Signal Transduction and Targeted Therapy·Xiaoling SongYingbin Liu
Dec 8, 2020·Frontiers in Genetics·Xuedong ChenHongyan Ge
Apr 3, 2021·Annals of Diagnostic Pathology·Alka Mary MathaiMatthew M Yeh
May 16, 2021·Journal of Experimental & Clinical Cancer Research : CR·Dan SongQingchuan Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.