Lasting changes induced by mild alcohol exposure during embryonic development in BDNF, NCAM and synaptophysin-positive neurons quantified in adult zebrafish

The European Journal of Neuroscience
Samantha MahabirRobert Gerlai

Abstract

Fetal alcohol spectrum disorder is one of the leading causes of mental health issues worldwide. Analysis of zebrafish exposed to alcohol during embryonic development confirmed that even low concentrations of alcohol for a short period of time may have lasting behavioral consequences at the adult or old age. The mechanism of this alteration has not been studied. Here, we immersed zebrafish embryos into 1% alcohol solution (vol/vol%) at 24 hr post-fertilization (hpf) for 2 hr and analyzed potential changes using immunohistochemistry. We measured the number of BDNF (brain-derived neurotrophic factor) and NCAM (neuronal cell adhesion molecule)-positive neurons and the intensity of synaptophysin staining in eight brain regions: lateral zone of the dorsal telencephalic area, medial zone of the dorsal telencephalic area, dorsal nucleus of the ventral telencephalic area, ventral nucleus of the ventral telencephalic area, parvocellular preoptic nucleus, ventral habenular nucleus, corpus cerebella and inferior reticular formation. We found embryonic alcohol exposure to significantly reduce the number of BDNF- and NCAM-positive cells in all brain areas studied as compared to control. We also found alcohol to significantly reduce the inten...Continue Reading

References

Feb 1, 1990·Alcoholism, Clinical and Experimental Research·L S MeyerE P Riley
Oct 1, 1986·Journal of Neurochemistry·P KnausH Rehm
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S E FraserG M Edelman
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·H T McMahonT C Südhof
Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·C I SzeL J Martin
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L C RønnE Bock
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·S L EastwoodP J Harrison
Feb 8, 2002·Molecular Neurobiology·P Durbec, H Cremer
Feb 9, 2002·Life Sciences·Kiyofumi YamadaToshitaka Nabeshima
Mar 29, 2003·Learning & Memory·Bai Lu
Apr 26, 2003·Neurobiology of Aging·Karyn M Frick, Stephanie M Fernandez
Oct 22, 2003·Physiology & Behavior·Manuel PortavellaMauricio R Papini
Feb 21, 2004·Nature Reviews. Neuroscience·Ralf Kleene, Melitta Schachner
May 22, 2004·BMC Neuroscience·Gerhard Heinrich, Carl John Pagtakhan
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Anders M HinsbyElisabeth Bock
Nov 3, 2004·Growth Factors·Devin K Binder, Helen E Scharfman
Apr 27, 2005·Journal of Alzheimer's Disease : JAD·P Hemachandra ReddyMaria Manczak
Jun 16, 2005·Experimental Biology and Medicine·Edward P Riley, Christie L McGee
Aug 3, 2005·Nature Reviews. Neuroscience·Larry S ZweifelDavid D Ginty
Sep 8, 2005·Brain Research Bulletin·F RodríguezC Salas
Oct 11, 2005·Behavioural Brain Research·Earl T LarsonRichard H Melloni
Dec 31, 2005·The Journal of Comparative Neurology·R Glenn Northcutt
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Scott E CountsElliott J Mufson

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Citations

Oct 3, 2018·International Journal of Molecular Sciences·Alberto Granato, Benjamin Dering
Jun 18, 2019·Alcoholism, Clinical and Experimental Research·Adam D CollierSarah F Leibowitz
Aug 8, 2020·Frontiers in Pediatrics·Laura AlmeidaMaría Dolores Gómez-Roig
Nov 12, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Niti SharmaBhupesh Sharma
Jan 5, 2021·Frontiers in Behavioral Neuroscience·Alexis Buatois, Robert Gerlai
Jul 19, 2020·Neuroscience and Biobehavioral Reviews·Craig D C BaileyCheryl M McCormick
Apr 18, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dipashree ChatterjeeRobert Gerlai
Nov 6, 2021·Genesis : the Journal of Genetics and Development·Yohaan Fernandes, C Ben Lovely
Oct 24, 2021·Developmental Neurobiology·José Henrique Cararo, Eduardo Pacheco Rico

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