Lasting Gammaproteobacteria profile changes characterized hematological cancer patients who developed oral mucositis following conditioning therapy.

Journal of Oral Microbiology
Jean-Luc C MougeotFarah Bahrani Mougeot

Abstract

Background: Oral mucositis (OM) is a common side effect of conditioning therapy implemented before hematopoietic stem cell transplantation (HSCT). The role of oral microbiome in OM is not fully elucidated. Objective: To determine oral microbiome profile changes post-conditioning in HSCT patients who developed moderate OM, or mild to no OM. Design: Patient groups were: Muc0-1 with OM-score = 0-1 (43 paired samples) and Muc2 with WHO OM-score = 2 (36 paired samples). Bacterial DNA was isolated from oral samples (saliva, swabs of buccal mucosa, tongue, and supragingival plaque) at pre-conditioning (T 0 ), post-conditioning mucositis onset (T Muc ), and one-year post-conditioning (T Year ). 16S-rRNA gene next-generation sequencing was used to determine the relative abundance (RA) of >700 oral species. Alpha-diversity, beta-diversity and linear discriminant analyses (LDA) were performed Muc2 versus Muc0-1. Results: Muc2 oral microbiome alpha- and beta-diversity differed between T 0 and T Muc . Muc2 alpha-diversity and Muc0-1 beta-diversity did not differ between T 0 and T Year . T 0 to T Muc LDA scores were significant in Muc2 for Gammaproteobacteria. For Muc2 patients, the average RA decreased for Haemophilus parainfluenza, a speci...Continue Reading

References

Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Linda S EltingAdam S Garden
Dec 25, 2007·Dental Clinics of North America·Rajesh V LallaDouglas E Peterson
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoMary Horowitz
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·J Gregory CaporasoRob Knight
Sep 18, 2010·Oral Diseases·S T Sonis
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Jul 9, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Deborah P SaundersUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Mar 17, 2015·Current Opinion in Oncology·Alessandro Villa, Stephen T Sonis
Nov 2, 2015·Journal of Endodontics·Brenda P F A GomesBruce J Paster
Apr 8, 2016·Journal of Dental Research·R M VasconcelosP M Corby
Apr 12, 2016·Journal of Oral Microbiology·Jean-Luc C MougeotFarah K Bahrani Mougeot
Nov 9, 2016·Journal of Dental Research·C P FurquimF R F Teles
Nov 23, 2017·Frontiers in Microbiology·Abhishek KaulShyamal D Peddada
May 24, 2018·Nucleic Acids Research·Enis AfganDaniel Blankenberg
Mar 21, 2019·Journal of Oral Microbiology·Jean-Luc C MougeotFarah Bahrani Mougeot
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Jean-Luc C MougeotFarah B Mougeot
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Linda S Elting, Yu-Chia Chang
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Frederik K L SpijkervetArjan Vissink

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Citations

Dec 23, 2020·Journal of Clinical Medicine·Jean-Luc C MougeotFarah Bahrani Mougeot
Dec 30, 2020·BMC Bioinformatics·Min Jin HaChristine B Peterson

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Software Mentioned

BLAST
Galaxy
stem
PRIMER
R
ProbeSeq
All
Set
PERMANOVA
LEfSe

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