Late anaplastic gliomas in children previously treated for acute lymphoblastic leukemia

Pediatric Neuroscience
S Shapiro, J Mealey

Abstract

At least 33 cases of late anaplastic gliomas in children previously treated for acute lymphoblastic leukemia have been discussed in the literature including 20 well-documented cases. The frequency of this second malignancy is much greater than expected and may represent a 'new syndrome' with some genetic predisposition. Additionally, CNS prophylaxis which includes both radiation and intrathecal methotrexate appears to work synergistically in increasing the incidence of glial tumors especially multifocal tumors in these patients. The prognosis for these children is dismal but an aggressive treatment approach including surgery, interstitial radiation, and chemotherapy appears to improve survival.

Citations

Jul 1, 1993·Journal of Neuro-oncology·M WrenschM Yost
Nov 30, 2005·Journal of Neuro-oncology·Linda Nicolardi, Lisa M DeAngelis
Jul 10, 2003·Blood Cells, Molecules & Diseases·Smita Bhatia
Jul 1, 1995·Journal of Neurosurgery·B KaschtenA Stevenaert
Sep 19, 2008·Neuro-Chirurgie·J GrillC Kalifa
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Arnold C PaulinoBin S Teh
Mar 19, 2011·Pediatric Hematology and Oncology·N BertorelloF Fagioli
Jun 21, 2008·Journal of Neuro-oncology·Maurizio SalvatiRoberto Delfini
May 3, 2011·Journal of Neuro-oncology·Hideo NakamuraJun-ichi Kuratsu

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