Late anastomotic leakage after low anterior resection in rectal cancer patients: clinical characteristics and predisposing factors

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Seok-Byung LimJin Cheon Kim

Abstract

The purpose was to examine the clinical characteristics and predisposing factors of late anastomotic leakage following low anterior resection for rectal cancer. We retrospectively evaluated the clinicopathological features of patients who experienced anastomotic leakage after low anterior resection for rectal cancer. Patients were divided into two groups according to the time to leakage: early leakage (within 30 days postoperatively) and late leakage (after 30 days postoperatively). Clinicopathological characteristics were compared between the two groups. Anastomotic leakage occurred in 141 patients. Anastomotic leakage was diagnosed at a median of 17 (range 0-886) days postoperatively; 85 (60.3%) and 56 (39.7%) were categorized as the early and late leakage groups, respectively. Radiotherapy (hazard ratio 5.007; 95% CI 2.208-11.354; P < 0.0001) was the only significant independent predisposing factor for late leakage. Diverting stoma did not protect against late leakage. The late leakage group more frequently had the fistula type (46.4% vs. 10.6%; P < 0.001) and less frequently needed laparotomy (55.4% vs. 78.8%; P = 0.001). The rate of long-term stoma over 1 year was greater in the late leakage than the early leakage group (5...Continue Reading

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Citations

Sep 22, 2018·Diseases of the Colon and Rectum·Cloë L SparreboomUNKNOWN Dutch ColoRectal Audit group
Feb 8, 2020·Diseases of the Colon and Rectum·Daniel Kverneng HultbergMartin Rutegård
Oct 13, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·H JutestenM L Lydrup
Aug 9, 2020·Gastroenterology Research and Practice·Yifan XvQingsong Tao
Jul 21, 2020·World Journal of Gastroenterology : WJG·Claire Pm van HelsdingenJoep Pm Derikx
Aug 19, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Anne-Loes K WarpsUNKNOWN Dutch ColoRectal Audit

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