Late clinical outcomes after implantation of drug-eluting stents coated with biodegradable polymers: 3-year follow-up of the PAINT randomised trial

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Pedro A LemosExpedito E Ribeiro

Abstract

The long-term clinical performance of drug-eluting stents (DES) coated with biodegradable polymers is poorly known. A total of 274 coronary patients were randomly allocated to paclitaxel-eluting stents, sirolimus-eluting stents, or bare metal stents (2:2:1 ratio). The two DES used the same biodegradable polymers and were identical except for the drug. At three years, the pooled DES population had similar rates of cardiac death or myocardial infarction (9.0% vs. 7.1; p=0.6), but lower risk of repeat interventions (10.0% vs. 29.9%; p<0.01) than controls with bare stents. The cumulative 3-year incidence of definite or probable stent thrombosis in the pooled DES group was 2.3% (first year: 1.8%; second year: 0.4%; third year: zero). There were no significant differences in outcomes between paclitaxel- and sirolimus-eluting stents. The biodegradable-polymer coated DES releasing either paclitaxel or sirolimus were effective in reducing the 3-year rate of re-interventions.

References

May 26, 2009·JACC. Cardiovascular Interventions·Robert A ByrneAdnan Kastrati
Aug 12, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Pedro A LemosUNKNOWN PAINT trial investigators
Jun 22, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Scot GargStephan Windecker

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Citations

Apr 4, 2013·Heart, Lung & Circulation·Anthony M SammelNigel Jepson
Apr 20, 2013·Expert Review of Medical Devices·Pedro A Lemos, Igor Bienert
Oct 6, 2015·International Journal of Cardiology·Panagiotis Petrou, Sofia Dias
Oct 21, 2015·The Cochrane Database of Systematic Reviews·Juliet HockenhullAmisha Patel
Oct 9, 2021·Journal of the American Heart Association·Raffaele PiccoloUNKNOWN Coronary Stent Trialists’ (CST) Collaboration

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