PMID: 6968810Nov 1, 1980Paper

Late clonal selection and expansion of the TEPC-15 germ-line specificity

The Journal of Experimental Medicine
J Fung, H Kohler

Abstract

The maturation of the antibody response to phosphorylcholine (PC) in neonatal BALB/c mice was studied. A T cell-independent class 1 1 PC-antigen, 3-(p-azophenyl phosphorylcholine)-N-acetyl-L-tyrosylglycylglycine lipopolysaccharide, was synthesized and used to immunize neonatal mice of different ages. The earliest anti-PC hemolytic plaque-forming response could be induced in 1-d-old neonates. Idiotype analysis on these early anti-PC antibodies showed that the response was not TEPC-15 dominant although TEPC-15-positive plaque-forming cells were detected. However, idiotype analysis of the anti-PC-LPS response in 7 d or older animals indicated that clonal dominance had been established. Similar results were obtained in splenic fragment culture with cells from neonatal livers and spleens. PC-specific precursors were detected in the liver of 1-d-old neonates, whereas the spleen of those animals contained no precursors for PC. Precursors for PC residing in the neonatal liver are not TEPC-15 dominant, whereas the splenic PC precursors of 5- to 6-day-old animals express the TEPC-15 idiotype dominatly. These findings demonstrate that during ontogeny PC-specific B cells appear before the TEPC-15 clone becomes dominant. Thus clonal dominan...Continue Reading

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Citations

Apr 1, 2009·Immunology and Cell Biology·Tigran K DavtyanMichael D Grant
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S C RileyR T Ogata
Jul 1, 1988·The Journal of Experimental Medicine·G D YancopoulosF W Alt
Apr 6, 2016·Frontiers in Immunology·Heinz KohlerSrinivas V Kaveri
Jun 1, 1984·Immunological Reviews·K Bottomly
Jan 1, 1992·International Reviews of Immunology·J M Teale, C A Medina
Jun 1, 1985·European Journal of Immunology·K S HathcockR J Hodes
Mar 29, 1985·Science·R M PerlmutterL E Hood

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