Late effects of chemoradiotherapy in pediatric Hodgkin's disease

Journal of Chemotherapy
S GözdasogluI Haluk Gökçora

Abstract

We treated 137 Turkish children with biopsy-proven Hodgkin's disease, followed up between the years 1964 and 1989. Most patients were treated and were in advanced stage with histological subtype of mixed cellularity (67.5%). Radiotherapy (Mantle form) and/or MOPP, ABVD and OPPA combination chemotherapy regimens were used in 75.84% of patients. The follow-up period in these patients ranged from 5 to 24 years. The late effects in 28 patients who were evaluated for the late sequelae of chemoradiotherapy are presented. Seven out of 28 patients showed retarded sexual maturation. Testicular and ovarian functions were assessed in 11 patients, all of whom showed elevated serum FSH levels and 2 azoospermia. Analysis of thyroid functions was carried out in patients receiving radiotherapy to the neck. The thyroid gland was palpable in 6 patients. Further analysis showed diffuse hyperplasia in 5 and nodular in 1 patient. The nodule was excised and reported as "nodular colloidal goiter". Two patients had elevated TSH levels. "Swan-like neck" was observed in 3 patients who had received 40 to 42 Gy radiotherapy to the neck. Cirrhosis due to chronic hepatitis B infection was diagnosed in 2 patients as an unusual late complication. The secondar...Continue Reading

References

Jan 1, 1986·American Journal of Diseases of Children·Y TakaueJ van Eys
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·E D KreuserH Heimpel
Jan 1, 1994·Medical and Pediatric Oncology·D M GreenE A Stephens

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Citations

Jul 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Metin DemirkayaOkan Akacı

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