Late effects of pelvic rhabdomyosarcoma and its treatment in female survivors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sheri L SpuntAllison L Hester

Abstract

To document the spectrum and severity of late effects in female survivors of pelvic rhabdomyosarcoma. We reviewed the demographic, diagnostic, treatment, and outcome data of the 26 females treated for pelvic rhabdomyosarcoma at our institution between March 1962 and December 1996 who survived free of disease for 5 or more years. Adverse effects that occurred 5 or more years after diagnosis were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0. The most common tumor sites were vagina (n = 7), pelvis/retroperitoneum (n = 6), and bladder (n = 4). All patients received chemotherapy (alkylating agent, n = 23; doxorubicin, n = 16); 22 received radiotherapy (median dose, 46 Gy). Median follow-up of the 23 survivors was 20.3 years. Late effects occurred in 24 patients, 23 of whom had grade 3/4 late effects (median grade 3/4 late effects per patient, three; range, zero to 14). Fourteen patients (54%) required surgery for late complications. The 22 patients who had received radiotherapy had a greater median number of late effects per patient than did the remaining four (9.5 v one; P = .002). The median number of late effects per patient was higher in the 12 patients treated dur...Continue Reading

References

Apr 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R HeynH M Maurer
Jan 15, 1988·Cancer·H M MaurerJ Ortega
Aug 1, 1995·Medical and Pediatric Oncology·S C KasteL C Bowman
Mar 1, 1994·Gynecologic Oncology·C LevenbackT W Burke
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R HeynH M Maurer
Oct 6, 1997·Journal of Pediatric Surgery·E L MichalkiewiczC B Pratt
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·S R RoseR L Heideman
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·A C PaulinoB C Wen
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O OberlinUNKNOWN International Society of Paediatric Oncology Sarcoma Committee, Intergroup Rhabdomyosarcoma Study Group, Italian Cooperative
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D. NunnsM. Davy
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C BrenemanWilliam M Crist
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Pernille T JensenDavid Machin
Sep 25, 2003·JAMA : the Journal of the American Medical Association·Melissa M HudsonUNKNOWN Childhood Cancer Survivor Study Investigators
Feb 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Susan R RoseMelissa M Hudson
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cindy L Carmack TaylorDiane C Bodurka
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brad J ZebrackLonnie K Zeltzer
Aug 7, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara A Jereczek-FossaJacek Jassem

❮ Previous
Next ❯

Citations

Mar 31, 2009·Journal of Neuro-oncology·E Brannon MorrisThomas E Merchant
Aug 7, 2007·The Lancet Oncology·Nicolas Magné, Christine Haie-Meder
Nov 28, 2012·Nature Reviews. Urology·Karim T SadakJeffrey S Dome
Jun 15, 2007·Current Opinion in Urology·Karen DriscollFernando Ferrer
Mar 8, 2008·Pediatric Radiology·Rick R Van RijnJohannes H M Merks
Nov 1, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank HeinzelmannMartin Weinmann
Nov 15, 2011·Journal of Pediatric Surgery·Israel Fernandez-PinedaBhaskar N Rao
Aug 6, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nicolas MagnéYacine Merrouche
Nov 17, 2009·Primary Care·Kevin C OeffingerWendy Landier
Jul 31, 2009·Journal of Pediatric Urology·Hsi-Yang WuRichard B Womer
Mar 5, 2009·Best Practice & Research. Clinical Gastroenterology·Frédéric Di Fiore, Eric Van Cutsem
Oct 16, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antonin LevyChristine Haie-Meder
Apr 9, 2008·Hematology/oncology Clinics of North America·Melissa M Hudson
Mar 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Nicolas MagnéChristine Haie-Meder
Feb 19, 2013·Pediatric Blood & Cancer·Daniel M GreenMelissa M Hudson
Apr 11, 2012·Pediatric Blood & Cancer·Steven W WarmannJörg Fuchs
May 9, 2012·The American Journal of Medicine·Lisa M KoppEmmanuel Katsanis
Aug 4, 2012·Pediatric Clinics of North America·Gwen M Grimsby, Michael L Ritchey
Dec 14, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yves RéguerreDaniel Orbach
Mar 17, 2015·Seminars in Pediatric Surgery·Sarah M Lambert
Feb 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monika L MetzgerDaniel M Green
Jun 9, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daphne A Haas-KoganStephanie A Terezakis
Jun 22, 2017·Archives of Gynecology and Obstetrics·Dimitrios NasioudisKevin Holcomb
Aug 17, 2018·Current Opinion in Obstetrics & Gynecology·Kathryn Stambough, Krista J Childress
Feb 23, 2018·Current Urology Reports·Amanda F Saltzman, Nicholas G Cost
Mar 22, 2006·Pediatric Blood & Cancer·Pamela GaillardStephen X Skapek
May 22, 2018·Pediatric Blood & Cancer·Veronique Minard-ColinUNKNOWN International Society of Pediatric Oncology Sarcoma Committee, the Children's Oncology Group, the Italian Cooperative Soft T
Aug 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Edouard RomanoCyrus Chargari
Jul 18, 2020·Journal of Pediatric Surgery·Daniel S RheeUNKNOWN American Pediatric Surgical Association Cancer Committee
Apr 6, 2021·Pediatric Blood & Cancer·Colette J ShenKaren J Marcus
Jul 19, 2021·Practical Radiation Oncology·Grace C Blitzer, Kristin A Bradley
Aug 21, 2021·Seminars in Pediatric Surgery·Fuchs JWarmann Sw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.