Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth

International Journal of Radiation Oncology, Biology, Physics
Chong DuanJoel R Garbow

Abstract

Glioblastoma (GBM) remains incurable, despite state-of-the-art treatment involving surgical resection, chemotherapy, and radiation. GBM invariably recurs as a highly invasive and aggressive phenotype, with the majority of recurrences within the radiation therapy treatment field. Although a large body of literature reporting on primary GBM exists, comprehensive studies of how prior irradiation alters recurrent tumor growth are lacking. An animal model that replicates the delayed effects of radiation therapy on the brain microenvironment, and its impact on the development of recurrent GBM, would be a significant advance. Cohorts of mice received a single fraction of 0, 20, 30, or 40 Gy Gamma Knife irradiation. Naïve, nonirradiated mouse GBM tumor cells were implanted into the ipsilateral hemisphere 6 weeks postirradiation. Tumor growth was measured by magnetic resonance imaging, and animal survival was assessed by monitoring weight loss. Magnetic resonance imaging results were supported by hemotoxylin and eosin histology. Tumorous lesions generated from orthotopic implantation of nonirradiated mouse GBM tumor cells into irradiated mouse brain grew far more aggressively and invasively than implantation of these same cells into non...Continue Reading

Citations

Apr 27, 2019·Neurochemical Research·Thomas N SeyfriedPurna Mukherjee
Aug 1, 2020·Frontiers in Oncology·Xuehai WangNing Yang
Dec 31, 2020·Neuropathology and Applied Neurobiology·Gabriela CarrenoJuan Pedro Martinez-Barbera

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