PMID: 16507272Mar 2, 2006Paper

Late effects of treatment for Hodgkin lymphoma

Journal of the National Comprehensive Cancer Network : JNCCN
Debra L Friedman, Louis S Constine

Abstract

With advances in multimodality therapy, survival from Hodgkin lymphoma (HL) now exceeds 80%, resulting in a large cohort of survivors who are at risk for adverse long-term sequelae of therapy. This risk is complicated by possible endogenous predispositions to developing late effects, which relate to the patient's underlying susceptibility to HL. Finally, the impact of HL on the host can compromise organ function. This article reviews the possible dominant late effects for survivors of HL and strategies for monitoring and screening. As therapy for HL has changed and evolved, so has the spectrum of late effects. Mortality from HL has decreased, whereas delayed effects of therapy have increased. Refinements in therapy to decrease toxicity have occurred in response to the success in curing HL. Thus, modifications in therapeutic protocols using a risk-adapted strategy have reduced the use of alkylating agents, anthracyclines, and radiotherapy, which are associated with adverse long-term sequelae. The most clinically evident sequelae are those involving the endocrine and cardiovascular systems, and the most morbid are hematologic and solid second malignancies. Primary and secondary prevention strategies can be developed as knowledge ...Continue Reading

Citations

Oct 1, 2008·Expert Review of Hematology·Dennis A EichenauerUNKNOWN German Hodgkin Study Group
Nov 12, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Lonneke van de Poll-FranseUNKNOWN EORTC Quality of Life Group
Dec 12, 2012·American Journal of Hematology·Maike SauerElke Pogge von Strandmann
Jul 1, 2007·Current Hematologic Malignancy Reports·Michael Jacob AdamsSteven E Lipshultz
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Sophie D FossåAlv A Dahl
Sep 25, 2007·Blood·Marie L De BruinFlora E van Leeuwen
Jun 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciIlaria Guiggi
Oct 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra L FriedmanCindy L Schwartz
Oct 11, 2014·Journal of the National Cancer Institute·Arnold L PotoskyUNKNOWN AYA HOPE Study Collaborative Group
Feb 26, 2014·Deutsches Ärzteblatt International·Ulrich KeilholzAngelika Eggert
Mar 25, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C JacksonA Wotherspoon

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