PMID: 1968502Feb 1, 1990

Late effects of X-irradiation on haemopoietic stem cells in CBA/H mice

International Journal of Radiation Biology
S A Lorimore, E G Wright

Abstract

CBA/H male mice have been used to study the recovery of haemopoietic stem cells following 3 Gy whole-body X-irradiation. Despite significant proliferation haemopoietic stem cells (measured as spleen colony-forming units or CFU-S) did not recover to control values and their numbers remained sub-optimal at 600 days post-irradiation. At this time there were significant increases in both proliferation and self-renewal characteristics of the CFU-S but no impairment of the capacity of bone marrow cells to rescue and repopulate lethally irradiated transplant recipients.

References

May 1, 1993·International Journal of Radiation Biology·S A LorimoreE G Wright
Oct 13, 2018·Radiation Research·Kentaro AriyoshiMitsuaki A Yoshida
Feb 1, 1996·International Journal of Radiation Biology·G E WatsonE G Wright
Jan 1, 1993·International Journal of Radiation Biology·T GrandeJ A Bueren

Citations

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S HellmanR M Vigneulle
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Jul 1, 1969·The Journal of Experimental Medicine·R G WortonJ E Till
Dec 1, 1965·Journal of Cellular Physiology·D H Pluznik, L Sachs
Feb 11, 1982·Nature·M C MagliN Odartchenko

Related Concepts

Mice, Inbred CBA
Colony-Forming Units, Hematopoietic
Spleen Colony-forming Unit
Late Effect of Medical Intervention
Spleen
Spleen Tissue
Colony-Forming Units Assay
Bone Marrow Cells
Proliferation (Morphologic Abnormality)
Transplant Recipients

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