Late effects on renal glomerular and tubular function in childhood cancer survivors

Pediatric Blood & Cancer
Edit BárdiCsongor Kiss

Abstract

Late nephrotoxicity among childhood cancer survivors is poorly documented. We investigated 115 patients and 86 controls assessing serum cystatin C concentration (CysC), urinary N-acetyl-beta-D-glucosaminidase activity (NAG), and microalbuminuria. Proteinuria was quantified and electrophoresis performed. Polymorphism of the angiotensin convertase enzyme (ACE) gene was determined by genomic PCR. CysC was elevated in Wilms tumor (WT) patients. Gross proteinuria was observed in 30 patients including three patients with progressive proteinuria who improved on ACE-inhibitor treatment. Neither patients with proteinuria nor the entire study population differed from controls with respect to ACE polymorphism. Pathologically elevated urinary NAG was noted in 38% of leukemia/lymphoma, 54% of solid tumor, 20% of WT survivors. A similar distribution of pathological microalbuminuria was found. Mild-to-moderate subclinical glomerular and tubular damage can be identified in many childhood cancer survivors. However, most patients experience some spontaneous recovery from acute nephrotoxicity.

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Citations

Oct 9, 2007·Pathology Oncology Research : POR·Edit BárdiCsongor Kiss
Feb 26, 2009·Current Urology Reports·Margarett ShnorhavorianMartin A Koyle
Jan 20, 2010·Pathology Oncology Research : POR·Edit BardiCsongor Kiss
Jun 24, 2006·Journal of Pediatric Hematology/oncology·Zoltán SohajdaCsongor Kiss
May 2, 2012·Case Reports in Medicine·Egle SimanauskieneGilvydas Verkauskas
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Oct 15, 2020·Cancer Chemotherapy and Pharmacology·Eryk LatochMaryna Krawczuk-Rybak

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