PMID: 7543635Aug 1, 1995Paper

Late endothelial function of free and pedicled internal mammary artery grafts

The Journal of Thoracic and Cardiovascular Surgery
S S KushwahaM H Yacoub

Abstract

The internal mammary artery has greater long-term patency than the saphenous vein when used for coronary bypass grafting. Therefore, bilateral use of the internal mammary artery for grafting with the right internal mammary artery used as a "free" graft may result in improved graft survival. The study objectives were to compare the endothelial-dependent and -independent vasodilatory response in free and pedicled internal mammary artery grafts in patients who had previously undergone coronary surgery. Free (group 1, n = 8) and pedicled (group 2, n = 7) internal mammary artery grafts were studied by comparing the response to selective infusion of the endothelial-dependent vasodilator substance P (1.4 up to 22.4 pmol/min in doubling dose increments) followed by isosorbide dinitrate (2 mg over 2 minutes), in patients undergoing coronary angiography, 1 month to 6 years after coronary surgery. Maximal dilatory response to substance P was 8.7% +/- 1.8% in pedicled grafts compared with 8.8% +/- 2.3% in free grafts (p = not significant), with the dose response for both groups being similar. Infusion of isosorbide dinitrate produced only minimal further dilatation in both groups. No significant difference was found in endothelium-dependen...Continue Reading

References

Nov 1, 1992·The American Journal of Cardiology·L NoyezL K Lacquet
Oct 1, 1992·The Annals of Thoracic Surgery·C AcarJ L Guermonprez
Aug 1, 1992·British Heart Journal·E S AklM H Yacoub
Nov 1, 1992·The Annals of Thoracic Surgery·J M CunninghamR A Meek
Dec 1, 1991·The Annals of Thoracic Surgery·G S O'NeilM H Yacoub
Apr 1, 1991·Journal of the American College of Cardiology·G M FitzGibbonW J Keon
Apr 1, 1991·Journal of the American College of Cardiology·M G Bourassa
Jul 1, 1991·The Annals of Thoracic Surgery·D L GalbutT O Gentsch
Feb 1, 1990·The Annals of Thoracic Surgery·D L GalbutT O Gentsch
Apr 1, 1986·British Journal of Pharmacology·T B Bolton, L H Clapp
Sep 1, 1989·Circulation·H DrexlerT Bonzel
Feb 1, 1988·Journal of the American College of Cardiology·M E SheltonJ B Atkinson
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Aug 25, 1988·The New England Journal of Medicine·T F LüscherE Weber
Jan 2, 1986·The New England Journal of Medicine·F D LoopW C Sheldon
May 1, 1968·Circulation Research·W M Fam, M McGregor
Jan 1, 1984·Journal of Cardiovascular Pharmacology·R F FurchgottD Jothianandan
Nov 1, 1993·Current Opinion in Cardiology·M Turina

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Citations

Apr 8, 1998·Journal of the American College of Cardiology·R G Favaloro
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Soichiro Kitamura
Feb 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J M Cunningham
Nov 5, 2013·The Journal of Thoracic and Cardiovascular Surgery·Hadi Daood Toeg, Fraser Douglas Rubens
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Mario GaudinoGianfederico Possati
May 10, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nicola VistariniSiamak Mohammadi
Feb 15, 2020·Journal of Cardiac Surgery·Daniel YimAmer Harky
Feb 4, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Hendrick B Barner
Apr 18, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·I FukudaH Kamiya
Apr 20, 2020·The Journal of Thoracic and Cardiovascular Surgery·Mohamed MarzoukSiamak Mohammadi

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