Late functional improvement after lacunar stroke: a population-based study

Journal of Neurology, Neurosurgery, and Psychiatry
Aravind GaneshOxford Vascular Study

Abstract

Recovery in function after stroke involves neuroplasticity and adaptation to impairments. Few studies have examined differences in late functional improvement beyond 3 months among stroke subtypes, although interventions for late restorative therapies are often studied in lacunar stroke. Therefore, we compared rates of functional improvement beyond 3 months in patients with lacunar versus non-lacunar strokes. In a prospective, population-based cohort of 3-month ischaemic stroke survivors (Oxford Vascular Study; 2002-2014), we examined changes in functional status (modified Rankin Scale (mRS), Rivermead Mobility Index (RMI), Barthel Index (BI)) in patients with lacunar versus non-lacunar strokes from 3 to 60 months poststroke, stratifying by age. We used logistic regression adjusted for age, sex and baseline disability to compare functional improvement (≥1 mRS grades, ≥1 RMI points and/or ≥2 BI points), particularly from 3 to 12 months. Among 1425 3-month survivors, 234 patients with lacunar stroke did not differ from others in 3-month outcome (adjusted OR (aOR) for 3-month mRS >2 adjusted for age/sex/National Institutes of Health Stroke Scale score/prestroke disability: 1.14, 95% CI 0.75 to 1.74, p=0.55), but were more likely t...Continue Reading

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Citations

Mar 8, 2018·Immunology·Jodie StephensonSandra Amor
Feb 17, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Nick S WardKate Kelly
Apr 22, 2020·Aging·Alexander HammerHendrik Janssen
Jun 25, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Aravind GaneshPeter Malcolm Rothwell
Apr 2, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·India WalfordNick Ward
Jun 26, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Belén Rubio BallesterPaul F M J Verschure

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