Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas

Radiation Oncology
Adnan ElhammaliHiram A Gay

Abstract

To consolidate literature reports of serious late gastrointestinal toxicities after hypofractionated radiation treatment of pancreatic cancer and attempt to derive normal tissue complication probability (NTCP) parameters using the Lyman-Kutcher-Burman model. Published reports of late grade 3 or greater gastrointestinal toxicity after hypofractionated treatment of pancreatic cancer were reviewed. The biologically equivalent dose in 1.8 Gy fractions was calculated using the EQD model. NTCP parameters were calculated using the LKB model assuming 1-5% of the normal tissue volume was exposed to the prescription dose with α/β ratios of 3 or 4. A total of 16 human studies were examined encompassing a total of 1160 patients. Toxicities consisted of ulcers, hemorrhages, obstructions, strictures, and perforations. Non-hemorrhagic and non-perforated ulcers occurred at a rate of 9.1% and were the most commonly reported toxicity. Derived NTCP parameter ranges were as follows: n = 0.38-0.63, m = 0.48-0.49, and TD50 = 35-95 Gy. Regression analysis showed that among various study characteristics, dose was the only significant predictor of toxicity. Published gastrointestinal toxicity reports after hypofractionated radiotherapy for pancreatic c...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S M DeoreK A Dinshaw
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·F E HalbergT L Phillips
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·C BurmanM Goitein
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G J Kutcher, C Burman
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M MohiuddinF E Rosato
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F Ahmadu-SukaC E Whiteman
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·A L GoldsonO Pearson
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MohiuddinR Cantor
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S A Roberts, J H Hendry
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Y NishimuraM Abe
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeS M Bentzen
Jul 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Morten HoyerHans von der Maase
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Clint ParkRobert D Timmerman
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jan 2, 2009·Cancer·Daniel T ChangAlbert C Koong
Feb 23, 2010·International Journal of Radiation Oncology, Biology, Physics·Anand MahadevanCharles Vollmer
Mar 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Kazuhiko OgawaUNKNOWN JROSG Working Subgroup of Gastrointestinal Cancers
Mar 24, 2010·American Journal of Clinical Oncology·Jean-Claude M RwigemaSteven A Burton
Apr 20, 2010·International Journal of Radiation Oncology, Biology, Physics·James D MurphyAlbert C Koong
Sep 15, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mukund S DidolkarStuart Rabinowitz
May 10, 2011·International Journal of Radiation Oncology, Biology, Physics·Devin SchellenbergAlbert C Koong
Jun 11, 2011·International Journal of Radiation Oncology, Biology, Physics·Anand MahadevanMark Callery
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick J LoehrerAl B Benson
Apr 9, 2013·International Journal of Radiation Oncology, Biology, Physics·Michael D ChuongRavi Shridhar
Dec 4, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thomas B BrunnerMike Partridge

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Citations

Feb 1, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·E GkikaT B Brunner
Mar 6, 2018·International Journal of Radiation Biology·Masoud NajafiHamid Abdollahi
Jun 15, 2016·World Journal of Clinical Oncology·Vivek Verma
Jul 10, 2019·Australasian Physical & Engineering Sciences in Medicine·Ho LeeJinsil Seong
Nov 8, 2017·Abdominal Radiology·Eugene J KoayJoseph M Herman
Oct 2, 2020·Journal of Cancer Research and Clinical Oncology·Gian Carlo MattiucciVincenzo Valentini
Oct 31, 2018·Physics in Medicine and Biology·Shahad Al-WardBrian M Keller
Aug 9, 2018·Radiation Oncology·Andrew HuntEmma B Holliday
Jan 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Eric S DiffenderferKeith A Cengel
Aug 4, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hanbo ChenSuresh Senan
Aug 16, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Camprodon, F Huguet
Feb 3, 2020·The Lancet Oncology·Jacob S WittMichael F Bassetti

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Methods Mentioned

BETA
pancreatectomy

Software Mentioned

SAS

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