Late-night salivary cortisol in normal subjects and in patients with Cushing's syndrome

Postgraduate Medical Journal
K JeyaramanS N Dwivedi

Abstract

Late-night salivary cortisol is used as a screening test for Cushing's syndrome (CS) in many European and American countries. However, its utility has not been studied in an Asian-Indian population. To establish the reference range in Asian-Indians and to evaluate its usefulness in the diagnosis of CS. Three groups of subjects were studied: normal subjects, patients with suspected CS, and patients with proven CS. All participants collected saliva at 23:00 h using a Salivette. Salivary cortisol was measured using an automated electrochemiluminescence assay. There were 56 normal subjects, 40 patients with suspected CS, and 30 with proven CS. Of the 40 with suspected CS, three were confirmed to have CS. The remaining 37 served as control patients. The 97.5th centile of the late-night salivary cortisol concentrations in normal subjects was 10.87 nmol/l. The mean+/-SD 23:00 h salivary cortisol concentration in control patients and those with confirmed CS was 3.21+/-2.36 nmol/l and 32.33+/-44.14 nmol/l, respectively. All the control patients and 30.3% (10/33) of patients with CS had a salivary cortisol concentration of <10.87 nmol/l. With the use of a receiver operating characteristic curve, a cut-off of 4.55 nmol/l gave a sensitivit...Continue Reading

Citations

May 31, 2012·Endocrine·Zhanna E Belaya, Galina A Melnichenko
Apr 5, 2014·Indian Journal of Endocrinology and Metabolism·Ariacherry C AmminiSudhir Tripathi
Jul 22, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Nusret YilmazMustafa Kemal Balci
Oct 10, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amol P BukanNalini S Shah
Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Brandon P GalmNicholas A Tritos
May 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Nandini PrasadAbilash Nair
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Jul 7, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hande Mefkure OzkayaPinar Kadioglu
Mar 25, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stephan Petersenn

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