Late-onset alopecia areata: a retrospective study of 73 patients from Taiwan

Journal of the European Academy of Dermatology and Venereology : JEADV
M C WuW C Chen

Abstract

Alopecia areata (AA) is regarded to be mediated by autoimmune process, and manifests as patchy non-scarring hair loss with occult onset. Little is known about AA occurring later in life. To define the characteristics of late-onset AA. Patients with first onset of AA at age 50 years and above were retrospectively recruited from two separate institutes in southern and northern Taiwan. The onset age, patterns, severity, past history, serological findings and therapeutic responses were reviewed. Seventy-three AA patients were enrolled, including 49 females (67%) and 24 males (33%). The onset age ranged from 50-78 years with the median age of 57 years. Multifocal lesions (41%) constituted the most common pattern and 55% of the recruited patients had a hair loss of less than 10%. Seventeen patients (23%) had co-existent dermatological or systemic diseases while six patients (8%) had a history of malignancy. Among 27 patients (37%) with available laboratory data, positive anti-nuclear antibody, anti-microsomal antibody and anti-thyroglobulin antibody was demonstrated in 26%, 40% and 30% of them, respectively. Association with personal or family history of atopy was absent. In 15 patients of follow-up longer than 6 months, a complete h...Continue Reading

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Citations

Sep 25, 2014·Clinical and Experimental Dermatology·S F LiX Zhang
May 2, 2014·Autoimmunity·Hosik SeokWoo-Young Sim
Jan 19, 2017·Anais Brasileiros De Dermatologia·Rosana LazzariniAna Luisa Nasser Erthal
Feb 1, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin Jahn-BasslerGeorg Stingl
Feb 1, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin Jahn-BasslerGeorg Stingl
Aug 15, 2015·Annals of Dermatology·Yong Hyun JangDo Won Kim
Aug 9, 2018·American Journal of Clinical Dermatology·Poonkiat Suchonwanit, Amy J McMichael
Mar 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A LyakhovitskyA Barzilai
Jul 22, 2018·Journal of the American Academy of Dermatology·Solam LeeWon-Soo Lee
Jan 21, 2021·Journal of the American Academy of Dermatology·Ki-Hun KimBark-Lynn Lew
Aug 2, 2019·Skin Appendage Disorders·Calvin T SungNatasha Atanaskova Mesinkovska

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